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Chitosan – poly(butylene succinate) scaffolds and human bone marrow stromal cel...
Costa-Pinto, A. R.; Correlo, V. M.; Sol, P.; Bhattacharya, Mrinal; Srouji, Samer; Livne, Erella; Reis, R. L.; Neves, N. M.Tissue engineering sustains the need of a three-dimensional (3D) scaffold to promote the regeneration of tissues in volume. Usually, scaffolds are seeded with an adequate cell population, allowing their growth and maturation upon implantation in vivo. Previous studies obtained by our group evidenced significant growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) w...
Scaffolds based bone tissue engineering : the role of chitosan
Costa-Pinto, A. R.; Reis, R. L.; Neves, N. M.As life expectancy increases, malfunction or loss of tissue caused by injury or disease leads to reduced quality of life in many patients at significant socioeconomic cost. Even though major progress has been made in the field of bone tissue engineering, present therapies, such as bone grafts, still have limitations. Current research on biodegradable polymers is emerging, combining these structures with osteoge...
Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs
Silva, M. L. Alves da; Martins, A.; Costa-Pinto, A. R.; Costa, P.; Faria, Susana, 1972-; Gomes, Manuela E.; Reis, R. L.; Neves, N. M.Mesenchymal stem cells (MSCs) have been recognized for their ability to differentiate into cells of different tissues such as bone, cartilage, or adipose tissue, and therefore are of great interest for potential therapeutic strategies. Adherent, colony-forming, fibroblastic cells were isolated from human bone marrow aspirates, from patients undergoing knee arthroplasties, and the MSCs phenotype characterized by...
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