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Oxidative Stress in Cyclosporine-Induced Hypertension: Evidence of Beneficial E...
Reis, F.; Rocha-Pereira, P.; Lemos, E. Teixeira de; Parada, B.; Baptista, S.; Figueiredo, A.; Santos-Silva, A.; Costa-Almeida, C.; Mota, A.The aim of this study was to evaluate the effect of cyclosporine (CsA) on oxidative stress as well as the use of a nitric oxide (NO) donor, the organic nitrate isosorbide-5-mononitrate (Is-5-Mn), to prevent or reverse CsA-induced toxicity, namely on the vascular NO-cGMP pathway or on oxidative equilibrium. The following rat groups (n = 8) were tested: (1) a control group; (2) the CsA group (5 mg/kg/d for 7 week...
Dual Effect of Nitrate Therapy for Cyclosporine-Induced Hypertension on Vascula...
Reis, F.; Lemos, E. Teixeira de; Almeida, L.; Parada, B.; Garrido, A. P.; Rocha-Pereira, P.; Santos-Silva, A.; Santos-Dias, J.; Dinis, A.The present study sought to evaluate the prevention and reversion effects of isosorbide-5-mononitrate (Is-5-Mn) on the development of hypertension (HT) and on the underlying vascular and platelet morphofunctional disturbances, using an animal model of cyclosporine (CsA)-induced HT. The following rat groups (n = 8) were tested: (1) a control group (orange juice, for 7 weeks); (2) the CsA group (5 mg/kg/d for 7 w...
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