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Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...

Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...

Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 C...

Mitoxantrone (MTX) is a chemotherapeutic agent that emerged as an alternative to anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress and mitochondrial-impaired function proposed as possible mechanisms. This work aimed to investigate the relevance of these mechanisms to the MTX toxicity in H9c2 cells, using therapeutic concentrations. The observed cytotoxicity of MTX was t...

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...

Intervenção clínica e nutricional em pacientes com diabetes mellitus tipo 2 não...

Objetivos: O presente estudo teve como objetivo avaliar em que medida o aconselhamento nutricional e a intensificação do acompanhamento clínico permitem melhorar o controlo metabólico de uma amostra de pacientes com diabetes mellitus tipo 2 não controlada e com excesso de peso/obesidade. Material e Métodos: Ensaio clínico controlado randomizado com três meses de duração realizado no Hospital de Sousa Martins da...

Partner support, social-cognitive variables and their role in adherence to self...

In Portugal, diabetes affects 11.7% of the population, of whom about 90% have type 2 diabetes. Patients and their partners are affected and the latter have a direct impact on patients’ adaptation to diabetes. A large proportion of patients, at diagnosis, have to readjust their daily routines in order to integrate self-care behaviours related to diabetes. The goal of this study was to analyse the relationship am...

Intervenção precoce: estudo exploratório sobre a prática de uma equipa disciplinar

Cada vez mais o processo de ensino-aprendizagem se revela orientado para a igualdade de oportunidades sejam elas, educativas ou sociais. Partindo deste pressuposto, podemos referir que o jardim-de-infância/escola não deve ter como objectivo exclusivo a transmissão de conteúdos, mas de igual modo, desenvolver competências de forma a preparar as crianças, para a sua vida em sociedade, ensinando-as a conviver, int...

Processo de tomada de decisão na saúde : a adesão terapêutica na diabetes Tipo 2

Role of catecholamines and reactive oxygen species in the mechanism of oxidativ...

Doutoramento em Toxicologia ; PhD Degree - Toxicology

Prática de parapente e comportamentos de risco: uma análise a partir do conceit...

Este estudo analisa, a partir do conceito de redoma sensorial (Almeida, 2008), aspectos que permeiam a atuação dos praticantes da modalidade parapente. Foi possível verificar, através de uma pesquisa descritivo-exploratória, que o domínio da técnica e o uso de equipamentos adequados, apesar de imprescindíveis, não garantem o êxito desses atores. Muitas vezes as situações de risco vivenciadas agregam, num primei...