Encontrados 11 documentos, a visualizar página 1 de 2
PHD2 regulates arteriogenic macrophages through TIE2 signaling
Hamm, Alexander; Veschini, Lorenzo; Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Squadrito, Mario Leonardo; Henze, Anne-TheresOcclusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, which promotes the formation of collateral vessels and protects the skeletal muscle from ischaemic necrosis. However, the molecular mechanisms underlying this pr...
Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas : p...
Tiburcio, Marta; Costa, Sandra Maria Araújo da; Duarte, Maria de Fátima Pereira; Schmitt, Fernando C.; Filho, A. L.Breast cancer is the most common cause of cancer mortality among women worldwide. Among the several factors associated with breast cancer development, angiogenesis plays an essential role and has currently emerged as a potential diag¬nostic, prognostic and therapeutic target. Protease-activated receptor 1 (PAR1) and fibroblast growth factor receptor 1 (FGFR1) have important activities in tumor angiogenesis and ...
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
Araújo, Ana Paula; Costa, Bruno Marques; Correia, Ana L. Pinto; Fragoso, Maria; Ferreira, Paula; Ribeiro, Mário Dinis; Costa, Sandra Maria Araújo daTo investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 control...
Macrophage skewing by Phd2 haplodeficiency prevents ischemia by inducing arteri...
Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Roncal, Carmen; Oliveira, Rodrigo Leite de; Squadrito, Mario LeonardoThe authors are thankful to Dr. P. Carmeliet for scientific discussion and support. VE-Cadherin:CreERT and PDGFRB:Cre transgenic mice were generated at the Cancer Research UK (London, UK) and kindly donated by Dr. R. Adams. The IKKβ floxed mice are a generous gift of Dr. M. Karin (UCSD, La Jolla, CA). The hydroxylase-deficient PHD2 construct was given by Dr. P. Ratcliffe (Oxford, UK). ; PHD2 serves as an oxyge...
TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant th...
Lima-Ramos, Vítor; Pacheco-Figueiredo, Luís; Costa, Sandra Maria Araújo da; Pardal, Fernando; Silva, Ana; Amorim, Júlia; Lopes, José Manuel; Reis, R. M.TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. The Pro72 variant has been associated with a slower induction of apoptosis and may influence the risk of cancer deve...
Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ...
Costa, Sandra Maria Araújo da; Pinto, Daniela; Pereira, Deolinda; Vasconcelos, André; Lopes, Carlos Afonso; Osório, Teresa; Lopes, Carlos; Medeiros, RuiThe purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ...
DNA repair genetic polymorphisms and breast cancer in the Portuguese population
Costa, Sandra Maria Araújo daTese de Doutoramento Ciências da Saúde – Ciências Biológicas e Biomédicas ; Breast cancer is the leading cause of death among women in developing countries. Approximately 10% of all cases of breast cancer are inherited, exhibiting a familial pattern of incidence, which have been attributable to mutations in high penetrance susceptibility genes, such as BRCA1 and BRCA2. However, these mutations only account to ...
Association between functional EGF+61polymorphism and glioma risk
Costa, Bruno Marques; Ferreira, Paula; Costa, Sandra Maria Araújo da; Canedo, Paulo; Oliveira, Pedro; Silva, Ana; Pardal, Fernando; Suriano, SurianoEpidermal growthf actor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61in glioma susceptibility and prognosis. Experimental Design:A case-control study involving197 glioma patients and 570 controlswas done. Univariate and multivari...
Acetylation genotype and the genetic susceptibility to postate cancer in a Sout...
Costa, Sandra Maria Araújo da; Pinto, Daniela; Morais, António; Vasconcelos, André; Oliveira, Jorge; Lopes, Carlos; Medeiros, RuiEpidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke. METHODS. We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR–RFL...
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels
Longatto Filho, Adhemar; Martins, Albino; Costa, Sandra Maria Araújo da; Schmitt, Fernando C.We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFR-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson’s chi-square ðw2...
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