Understanding the dynamic behavior of living organisms is a great challenge in systems biology. To address this, computational dynamic modeling of metabolic networks is essential to guide experimentation and to explain properties of complex biological systems. Large-scale kinetic models at the reaction network level are usually constructed using mechanistic enzymatic rate equations and a large number of kinetic...
O objetivo do presente estudo foi analisar as alterações ultraestruturais nas vilosidades do jejuno de seis equinos submetidos à distensão intraluminal com solução salina. A pressão intraluminal foi mantida em 25cm de água durante duas horas. As amostras de mucosa intestinal colhidas às: zero hora; duas horas de distensão; e duas horas e 12h de descompressão foram analisadas por meio de microscopia eletrônica d...
Experimental and clinical evidence suggests that angiotensin II (AII) participates in renal development. Renal AII content is several-fold higher in newborn rats and mice than in adult animals. AII receptors are also expressed in higher amounts in the kidneys of newborn rats. The kidneys of fetuses whose mother received a type 1 AII receptor (AT1) antagonist during gestation present several morphological altera...
The specific growth rate is one of the most important process variables characterizing the state of microorganisms during fermentations mainly because the biosynthesis of many products of interest is often related with the values assumed by this parameter. In the particular case of the fed-batch operation of Escherichia coli for the production of recombinant proteins, it is important to maintain the specific gr...
O presente trabalho objetivou avaliar os efeitos de leguminosas anuais e perenes em cafezal em produção, principalmente no controle de invasores na época chuvosa, ciclagem de nutrientes e produtividade do cafezal. ; 2007
Mitogen-activated protein kinases (MAPK) may be involved in the pathogenesis of acute renal failure. This study investigated the expression of p-p38 MAPK and nuclear factor kappa B (NF-kappaB) in the renal cortex of rats treated with gentamicin. Twenty rats were injected with gentamicin, 40 mg/kg, im, twice a day for 9 days, 20 with gentamicin + pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor), 14 wit...
Esta publicação apresenta algumas formas de plantio de café, testadas pela Embrapa Rondônia, na perspectiva de se obter um melhor resultado para o controle de invasores prejuciais à cafeicultura do Estado de RO. ; 2005
O presente estudo visou identificar os nematóides responsáveis pelos ataques aos cafeeiros do Estado de Rondônia. ; 2005
Pemphigus foliaceus (PF) is an autoimmune bullous disease endemic in Brazil. Since serum IL-12 is increased in patients with PF and Langerhans cells (LC) produce IL-12, we titrated serum autoantibodies by indirect immunofluorescence, and quantified epidermal dendritic cells, known as LC, and dermal dendritic cells (DC). Biopsies of blistering lesions were obtained from 22 patients, 13 of whom were submitted to ...
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