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Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxy...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Esteves, Ana P.; Ćirić, Ana; Glamočlija, Jasmina; Martins, Anabela; Soković, MarinaMushroom extracts or isolated compounds may be useful in the search of new potent antimicrobial agents. Herein, it is described the synthesis of protected (acetylated) glucuronide derivatives of p-hydroxybenzoic and cinnamic acids, two compounds identified in the medicinal mushroom Ganoderma lucidum. Their antimicrobial and demelanizing activities were evaluated and compared to the parent acids and G. lucidum e...
Antimicrobial activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinna...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Esteves, Ana P.; Ćirić, Ana; Glamočlija, Jasmina; Martins, Anabela; Soković, MarinaGanoderma lucidumis one of the most famous traditional medicinal mushrooms, being used as functional food and in preventive medicines [1 ]. p-Hydroxybenzoic and cinnamic acids were previously identified, by our research group, in wild G. lucidum from Northeast of Portugal [2].Many studies suggest that phenolic compounds are rapidly metabolized in the human organism being glucuronidation the most prevalent meta...
Growth inhibitory activity of Coprinopsis atramentaria extract, phenolic acids...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Martins, Anabela; Esteves, Ana P.; Queiroz, Maria João R.P.Mushrooms represent an important source of compounds with antitumor and immunostimulating properties. Our attention is being focused on the capacity of phenolic acids from mushrooms to miHb1t the growth of different tumor cell lines. Croprinopsis atramentaria (Bull.: Fr.) Redhead, Vilgalys & Moncalvo, is a wild edible mushroom previously characterized by us for its nutritional composition, and also showed a not...
Synthesis of acetylated glucuronide derivatives of p-hydroxybenzoic and cinnami...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Martins, Anabela; Esteves, Ana P.; Queiroz, Maria João R.P.Dietary phenolic compounds are widely considered to contribute to health benefits in humans. However, little is known about their bioactive forms in vivo and the mechanisms by which they may contribute toward disease prevention. Moreover, many studies on the biological effects of phenolic compounds have ignored the question of their achievable concentrations in the circulation after ingestion as well as their m...
Phenolic acids in the wild mushroom Ganoderma lucidum and synthesis of some pos...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Martins, Anabela; Esteves, Ana P.; Queiroz, Maria João R.P.Ganoderma lucidum is one of the most extensive!) studied mushrooms due to its medicinal properties, p-Hydroxybenzoic acid was the most abundant phenolic acid found in this mushroom. after HPLC-DAD-MS analysis. In the present work we describe the synthesis of glucuronide and methyl derivatives of p-hydroxybenzoic acid, which arc two of the main circulating metabolites found in humans. Their biological activity i...
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