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Crosstalk between genetics, gene expression and biochemical markers supports sy...

Alteração de marcadores inflamatórios, imunidade inata e metabolismo do ferro n...

Expression of iron metabolism-related genes is altered in Familial Hypercholest...

Atherosclerosis (ATH) is the major cause of cardiovascular diseases (CVD) causing great morbidity and mortality. Typically, ATH develops and progresses silently for years, without symptoms. Familial Hypercholesterolemia (FH) is an autosomal genetic disorder characterized by high levels of total and LDL cholesterol, a familial history of hypercholesterolemia and premature ATH. Atherogenesis is characterized by a...

Crossroad between Inflammation, Iron and Lipids in Atherogenesis

Atherosclerosis (ATH) is recognized as a chronic inflammatory condition and it is the leading cause of cardiovascular disease. The process of atherogenesis is characterized by the accumulation and oxidation of LDL (oxLDL) in the vessel wall and subsequent infiltration and activation of immune cells, particularly monocytes in an earlier stage and, later on, lymphocytes. The infiltrated monocytes differentiate in...

The effect of pro-inflammatory conditions on iron homeostasis and atherogenesis

This work was supported by National Institute of Health Dr Ricardo Jorge, I.P, INSERM (Institut National de la Santé et de la Recherche Médicale), CNRS (Centre National de la Recherche Scientifique), ANR (Agence Nationale de la Recherche, France; ANR- 08-GENO-000) , Fundação para a Ciência e Tecnologia (Grant SFRH/BD/48671/2008) and BioFIG (B Center for Biodiversity, Functional and Integrative Genomics). ; Ath...

Iron/copper metabolism in Alzheimer’s disease: genetics and biomarkers in a Por...

This work was supported by Fundação Astrazeneca through the “Programa de Apoio à Investigação” . Presented at the “International Conference in Alzheimer’s Disease 2009 ; The distinction between normal aging and Alzheimer's disease (AD) is a relevant step to combat this disease efficiently. Thus, the identification of biomarkers and genetic factors underlying AD pathology is extremely important. Oxidative injur...

Preparação de copolímeros à base de 2-vinilpiridina com propriedades bactericidas

We report the development of two copolymers based on 2-vinylpyridine, styrene and divinylbenzene (2Vpy-Sty-DVB) with different porosity degrees. The copolymers were subsequently quaternized with methyl iodide. To prepare charge transfer complexes, the unmodified copolymers and their derivatives quaternized with methyl iodine were impregnated with iodine. The antibacterial properties of the polymers were evaluat...

Memórias enclausuradas : a institucionalização de doentes de Alzheimer em respo...

A investigação que se segue abraça as temáticas da doença de Alzheimer, lares de idosos e centros de dia. A doença de Alzheimer é incurável, requerendo uma intervenção bem estruturada de modo a possibilitar qualidade de vida aos idosos portadores desta doença. Através do presente estudo, procurou-se perceber a importância do ambiente físico ao redor do idoso com Alzheimer, como recurso potencial ao seu apoio. A...

Dor torácica no serviço de urgência do Hospital de Santo António em 2008 um e...

Medicina ; Medicine

Para além dos estudos de uso da informação arquivística: a questão da acessibil...

Este artigo objetiva discutir a questão da acessibilidade no âmbito dos estudos de uso da informação arquivística. Apontando os arquivos como importantes unidades de informação e o papel da arquivologia na contemporaneidade, aborda a concepção dos estudos híbridos de uso da informação no contexto arquivístico a partir da definição dos estudos de usuários. Neste contexto, discute a acessibilidade quanto à inform...