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Entrapment ability and release profile of corticosteroids from starch-based mic...
Silva, G. A.; Costa, F. J.; Neves, N. M.; Coutinho, O. P.; Dias, Alberto Carlos Pires; Reis, R. L.We previously described the synthesis of starchbased microparticles that were shown to be bioactive (when combined with Bioactive Glass 45S5) and noncytotoxic. To further assess their potential for biomedical applications such as controlled release, three corticosteroids with a similar basic structure—dexamethasone (DEX), 16-methylprednisonole (MP), and 16-methylprednisolone acetate (MPA) - were used as models ...
Soluble starch and composite starch Bioactive Glass 45S5 particles : synthesis,...
Silva, G. A.; Pedro, A. J.; Costa, F. J.; Neves, N. M.; Coutinho, O. P.; Reis, R. L.For many biomedical applications, biodegradable and simultaneously bioactive materials are desired. These materials should at the same time be able to support cell function and co-exist with the organism without triggering a relevant immune response. In this work, the synthesis as well as the bioactivity evaluation of newly developed polymer soluble potato starch and composite (with Bioactive Glass 45S5) micron...
Synthesis and evaluation of novel bioactive composite starch/bioactive glass mi...
Silva, G. A.; Costa, F. J.; Coutinho, O. P.; Radin, S.; Ducheyne, P.; Reis, R. L.The aim of the development of composite materials is to combine the most desired properties of two or more materials. In this work, the biodegradable character, good controlled-release properties, and natural origin of starch-based biomaterials are combined with the bioactive and bone-bonding properties of bioactive glass (BG). Novel, bioactive composite starch-BG microparticles were synthesized starting from a...
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