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Molecular prognostic factors in glioblastoma : state of the art and future chal...
Magalhães, Ana Xavier; Costa, Bruno MarquesGliomas account for the majority of primary tumors of the CNS, of which glioblastoma (GBM) is the most common and malignant, and for which survival is very poor. Despite significant inter- and intra-tumor heterogeneity, all patients are treated with a standardized therapeutic approach. While some clinical features of GBM patients have already been established as classic prognostic factors (e.g., patient age at ...
Insights into angiogenesis in non-small cell lung cancer : molecular mechanisms...
Mello, Ramon Andrade de; Costa, Bruno Marques; Reis, R. M.; Hespanhol, VenceslauWe would like to thank Dr. Miguel Nunes from Department of Informatic of Faculty of Medicine of the University of Porto, Porto, Portugal, for his help in technical support, and Prof. Henrique Queiroga, Department of Pneumology of Faculty of Medicine of the University of Porto, Porto, Portugal, for his critical contribution in this manuscript review ; Lung cancer is a highly prevalent disease worldwide. Current...
Mechanisms of initiation and reversal of drug-seeking behavior induced by prena...
Rodrigues, Ana João; Leão, Pedro; Pêgo, José M.; Cardona, Diana; Carvalho, M.; Oliveira, Mário; Costa, Bruno Marques; Carvalho, Ana FrankyWe would like to thank the members of the Neuroscience Research Domain at ICVS for all the helpful discussions and suggestions. We are especially thankful to the animal facility caretakers, and to Drs Sara Silva, António Melo and Ana Paula Silva and Dieter Fischer for their help ; Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structur...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaB.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls ; BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. ...
Molecular hallmarks of gliomas
Pojo, Marta; Costa, Bruno MarquesGliomas are a heterogeneous group of neoplasias that account for the majority of primary tumors of the central nervous system, of which glioblastoma multiforme is by far the most common and malignant subtype. These are particularly dramatic diseases, as they rank first among all human tumor types for the tumor‐related average years of life lost, and for which curative therapies are not yet available. Their etio...
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
Araújo, Ana Paula; Costa, Bruno Marques; Correia, Ana L. Pinto; Fragoso, Maria; Ferreira, Paula; Ribeiro, Mário Dinis; Costa, Sandra Maria Araújo daTo investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 control...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Molecular determinants of glioma risk and patient prognisis
Costa, Bruno MarquesTese de Doutoramento em Ciências da Saúde Ciências Biológicas e Biomédicas ; Gliomas are a heterogeneous group of neoplasias that account for the majority of primary tumors of the central nervous system, of which glioblastoma multiforme is by far the most common and malignant subtype. These are particularly dramatic diseases, as gliomas rank first among all human tumor types for the tumor‐related average year...
Association between functional EGF+61polymorphism and glioma risk
Costa, Bruno Marques; Ferreira, Paula; Costa, Sandra Maria Araújo da; Canedo, Paulo; Oliveira, Pedro; Silva, Ana; Pardal, Fernando; Suriano, SurianoEpidermal growthf actor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61in glioma susceptibility and prognosis. Experimental Design:A case-control study involving197 glioma patients and 570 controlswas done. Univariate and multivari...
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