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NEDD8: A new ataxin-3 interactor
Ferro, Anabela; Carvalho, Ana Luísa; Teixeira-Castro, Andreia; Almeida, Carla; Tomé, Ricardo J.; Cortes, Luísa; Rodrigues, Ana-João; Logarinho, ElsaMachado-Joseph disease (MJD/SCA3) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG tract in the coding portion of the ATXN3 gene. The presence of ubiquitin-positive aggregates of the defective protein in affected neurons is characteristic of this and most of the polyglutamine disorders. Recently, the accumulation of the neural precursor cell expressed developmentally downregul...
Towards a structural understanding of the fibrillization pathway in Machado-Jos...
Gales, Luís; Cortes, Luísa; Almeida, Carla; Melo, Carlos V.; Costa, Maria do Carmo; Maciel, P.; Clarke, David T.; Damas, Ana MargaridaMachado-Joseph’s disease is caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein ataxin-3. Except for the polyglutamine region, proteins associated with polyglutamine diseases are unrelated, and for all of these diseases aggregates containing these proteins are the major components of the nuclear proteinaceous deposits found in the brain. A...
Identification and proteolytic processing of procardosin A
Ramalho-Santos, Miguel; Veríssimo, Paula; Cortes, Luísa; Samyn, Bart; Beeumen, Jozef Van; Pires, Euclides; Faro, CarlosPlant aspartic proteinases contain a plant-specific insert (PSI) of about 100 amino acids of unknown function with no similarity with the other aspartic proteinases but with significant similarity with saposins, animal sphingolipid activator proteins. PSI has remained elusive at the protein level, suggesting that it may be removed during processing. To understand the molecular relevance of PSI, the proteolytic ...
Concepção do comportamento agressivo em alunos do 4º e 7º ano de escolaridade
Cortes, Luisa MariaDissertação de mestrado em Psicopatologia e Psicologia Clínica ; Este estudo tem por principal objectivo o conhecimento das diferentes formas de concepção da agressão em crianças e pré-adolescentes, tendo em conta a influência de três variáveis: nível de escolaridade ( 20 - 4a ano, 20 - 7o ano), sexo (20 masculino, 20 feminino.) e agressividade (7 - agressivos, 8 - não agressivos). A avaliação da concepção e...
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