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In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene suc...
Pinto, A. R.; Martins, Ana M.; Carlos, Magda; Correlo, V. M.; Sol, P.; Longatto Filho, Adhemar; Battacharya, Mrinal; Reis, R. L.; Neves, N. M.In tissue engineering, the evaluation of the host response to the biomaterial implantation must be assessed to determine the extent of the inflammatory reaction. We studied the degradation of poly(butylene succinate) and chitosan in vitro using lipase and lysozyme enzymes, respectively. The subcutaneous implantation of the scaffolds was performed to assess tissue response. The type of inflammatory cells present...
Human skin cell fractions fail to self-organize within a gellan gum/Hyaluronic ...
Cerqueira, M. T.; Silva, L. P. da; Santos, T. C.; Pirraco, Rogério; Correlo, V. M.; Marques, A. P.; Reis, R. L.Split-thickness autografts still are the current gold standard to treat skin, upon severe injuries. Nonetheless, autografts are dependent on donor site availability and often associated to poor quality neoskin. The generation of dermal–epidermal substitutes by tissue engineering is seen as a promising strategy to overcome this problematic. However, solutions that can be safely and conveniently transplanted in o...
Migration of “bioabsorbable” screws in ACL repair. How much do we know? a syste...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
Biological characterization of rabbit nucleus pulposus cells on a biphasic scaf...
van Uden, Sebastião; Correia, Joana Silva; Correlo, V. M.; Oliveira, Joaquim M.; Reis, R. L.Intervertebral disc (IVD) degeneration (IDD) is nowadays considered as the main physiological cause for low back pain (LBP). LBP is known to affect people of any age, having a world socioeconomic burden of 70 billion euros per year[1]. Current LBP treatments only treat the symptoms without solving the problem. So, finding new ways of treating IDD is finding new ways of reducing socioeconomic impact created by L...
Novel cork-polymer composites reinforced with short natural coconut fibres : ef...
Fernandes, E. M.; Correlo, V. M.; Mano, J. F.; Reis, R. L.Composites from high density polyethylene filled with cork powder and coconut short fibres, in two different ratios, were prepared in a twin-screw extruder followed by compression moulding process. The main motivation of this work was to improve the mechanical performance without compromising the use of high weight percentage of natural component used in the preparation of cork-based composites. The morphology ...
New biotextiles for tissue engineering : development, characterization and in v...
Almeida, L. R.; Martins, A. R.; Fernandes, E. M.; Oliveira, Mariana B.; Correlo, V. M.; Pashkuleva, I.; Marques, A. P.; Ribeiro, Ana S.This work proposes biodegradable textile-based structures for tissue engineering applications. We describe the use of two polymers, polybutylene succinate (PBS) proposed as a viable multifilamentand silk fibroin (SF), to produce fibre-based finely tuned porous architectures by weft knitting. PBS is here proposed as a viable extruded multifilament fibre to be processed by a textile-based technology. A comparativ...
Erratum to: Migration of “bioabsorbable” screws in ACL repair. How much do we k...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
Semiconductor gellan gum based composite hydrogels for tissue engineering appli...
Berti, F. V.; Marques, A. P.; Correlo, V. M.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Semiconductor hydrogels can be developed by combining the intrinsic electrical properties of semiconductors with the specific characteristics of hydrogels. These hydrogels have recently attracted much attention for applications in tissue engineering, especially formulations incorporating pyrrole and excellent bioco...
Chitosan – poly(butylene succinate) scaffolds and human bone marrow stromal cel...
Costa-Pinto, A. R.; Correlo, V. M.; Sol, P.; Bhattacharya, Mrinal; Srouji, Samer; Livne, Erella; Reis, R. L.; Neves, N. M.Tissue engineering sustains the need of a three-dimensional (3D) scaffold to promote the regeneration of tissues in volume. Usually, scaffolds are seeded with an adequate cell population, allowing their growth and maturation upon implantation in vivo. Previous studies obtained by our group evidenced significant growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) w...
Osteogenic differentiation of two distinct subpopulations of human adipose-deri...
Rada, Tommaso; Santos, T. C.; Marques, A. P.; Correlo, V. M.; Frias, A. M.; Castro, António G.; Neves, N. M.; Gomes, Manuela E.; Reis, R. L.The first stem cells considered for the reconstruction of bone were bone marrow mesenchymal stem cells (BMSCs). Subsequently, cells with similar marker expression panel and differentiation potential were found in new sources of cells, such as adipose tissue. This source of stem cells has a promising future in tissue-engineering applications, considering the abundance of this tissue in the human body, the easy h...
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