Background and Aims: The ability of Influenza A (infA) viruses to counteract and manipulate the host response to infection is well acknowledged. In addition, the activation of the PI3K/Akt survival pathway by the infA NS1 protein has been described as one of the strategies to delay the apoptotic response of the infected cell. As influenza B (infB) viruses differ genetically and phenotypically from infA viruses,...
Neuraminidase (NA) protein of influenza viruses has the particularity of being under antibody and antiviral drug selective pressure, as it is one of the main surface antigens and the target of neuraminidase inhibitors(NAIs). The aim of this study is to investigate the selective pressure(SP) acting on the NA of seasonal and pandemic influenza viruses. It comprises two objectives: (a)to evaluate the contribution ...
In 2007 started to be carried out for the first time in Portugal a study focused on influenza antiviral drug resistance. Three main objectives were established:(1)to determine the antiviral profile of influenza viruses to oseltamivir, zanamivir and amantadine;(2)to determine and monitor the baseline level of susceptibility along winter seasons and for each influenza sub(type);(3)to analyse and characterize the ...
Background: Genetic changes in influenza surface and internal genes can alter viral fitness and virulence. Mutation trend analysis and antiviral drug susceptibility profiling of A(H1N1)pdm09 viruses is essential for risk assessment of emergent strains and disease management. Objective: To profile genomic signatures and antiviral drug resistance of A(H1N1)pdm09 viruses and to discuss the potential role of mutate...
Avaliou-se a resposta de juvenis de carpa capim (Ctenopharyngodon idella) à inclusão de proteína bruta (PB) em dietas práticas, em um experimento com 120 juvenis e 80 dias de duração. As dietas eram compostas por farinha de carne suína, farelo de soja, milho e farelo de trigo com 22, 30, 36 ou 44% de PB. Dez juvenis (153,0±1,5g) por tanque (850L) foram alimentados duas vezes ao dia (3% da biomassa). Foi observa...
A hidatidose apresenta uma distribuição cosmopolita e encontra-se entre as zoonoses de maior importância a nível mundial. O parasita Echinococcus granulosus, responsável por esta doença, apresenta uma distribuição cosmopolita afectando diversas espécies de animais e, acidentalmente, o Homem. O objectivo do estudo é a obtenção do estado larvar do E. granulosus (protoescólices) para o estudo da fertilidade dos qu...
In Portugal, the processing tomato is of great economical importance. The maintenance of the quality of the final product is of growing preoccupation due to the ever increasing consumer demand. IPM has been considered as the best alternative due to the guarantee of some of these demands, in particular the non existence of pesticide residues. The objectives of the work carried out in the Ribatejo were to establi...
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