Encontrados 33 documentos, a visualizar página 1 de 4
Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering
Pereira, D. R.; Canadas, Raphael F.; Correia, Joana Silva; Marques, A. P.; Reis, R. L.; Oliveira, Joaquim M.It has been shown that hydrogel bilayered scaffolds combining cartilage- and bone-like layers are most advantageous for treating osteochondral defects. In this study, it is proposed the use of low acyl gellan gum (LAGG) for developing bilayered hydrogel scaffolds for osteochondral tissue engineering. The cartilage-like layer of the GG-based bilayered hydrogel scaffolds is composed of LAGG (2 wt%). By adding a 2...
Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffold...
Yan, Leping; Correia, Joana Silva; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; Oliveira, Joaquim M.; Oliveira, A. L.Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyo...
Development of nanofiber-reinforced hydrogel scaffolds for nucleus pulposus reg...
Thorvaldsson, A.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Gatenholm, P.; Walkenström, P.In this work a new method is presented to efficiently produce hydrogel scaffolds reinforced with nanofibers to show enhanced mechanical properties and improved structural integrity. The method is based on a combination of air brush spraying of a hydrogel and electrospinning of nanofibers. With air brush spraying the controllability is enhanced and the potential for scale-up increased. The developed method was u...
Hydrogels in acellular and cellular strategies for intervertebral disc regenera...
Pereira, D. R.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterial...
Migration of “bioabsorbable” screws in ACL repair. How much do we know? a syste...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...
Pereira, H.; Correia, Joana Silva; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; Oliveira, Joaquim M.Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...
Biological characterization of rabbit nucleus pulposus cells on a biphasic scaf...
van Uden, Sebastião; Correia, Joana Silva; Correlo, V. M.; Oliveira, Joaquim M.; Reis, R. L.Intervertebral disc (IVD) degeneration (IDD) is nowadays considered as the main physiological cause for low back pain (LBP). LBP is known to affect people of any age, having a world socioeconomic burden of 70 billion euros per year[1]. Current LBP treatments only treat the symptoms without solving the problem. So, finding new ways of treating IDD is finding new ways of reducing socioeconomic impact created by L...
In vivo biofunctional evaluation of hydrogels for disc regeneration
Reitmaier, Sandra; Kreja, Ludwika; Gruchenberg, Katharina; Kanter, Britta; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Perugini, V.Purpose Regenerative strategies aim to restore the original biofunctionality of the intervertebral disc. Different biomaterials are available, which might support disc regeneration. In the present study, the prospects of success of two hydrogels functionalized with anti-angiogenic peptides and seeded with bone marrow derived mononuclear cells (BMC), respectively, were investigated in an ovine nucleotomy model. ...
Chitosan nanofibers as scaffolds for peripheral nerve regeneration
Carvalho, C. R.; Correia, Joana Silva; Martins, A.; Oliveira, Joaquim M.; Reis, R. L.Publicado em : "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Damage to the Peripheral Nervous System (PNS) is remarkably common and occurs mainly from trauma or a complication of surgery [1]. Although recovery of nerve function occurs in some mild injuries, outcomes are frequently poor following severe trauma, resulting in long-term impairment of limb function, dysaesthesi...
Erratum to: Migration of “bioabsorbable” screws in ACL repair. How much do we k...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
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