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Novel methodology based on biomimetic superhydrophobic substrates to immobilize...
Lima, A. C.; Batista, P.; Valente, T.; Silva, A. S.; Correia, I. J.; Mano, J. F.Cell-based therapies for regenerative medicine have been characterized by the low retention and integration of injected cells into host structures. Cell immobilization in hydrogels for target cell delivery has been developed to circumvent this issue. In this work mesenchymal stem cells isolated from Wistar rats bone marrow (rMSCs) were immobilized in alginate beads fabricated using an innovative approach involv...
A bi-layer electrospun nanofiltration membrane for plasmid DNA recovery from fe...
Correia, Tiago R.; Antunes, Bernardo P.; Castilho, Pedro H.; Nunes, José C.; Amorim, M. T. Pessoa de; Escobar, I. C.; Correia, I. J.; Morão, A.The demanding ever-increasing quantities of highly purified biomolecules by bio-industries, has triggered the development of new, more efficient, purification techniques. The application of membrane-based technologies has become very attractive in this field, for their high throughput capability, simplicity of operation and scale-up. Herein we report the production of a bi-layer membrane by electrospinning (ES...
Novel methodology based on biomimetic superhydrophobic substrates to immobilize...
Lima, A. C.; Batista, P.; Valente, T.; Silva, A. S.; Correia, I. J.; Mano, J. F.The low retention/integration of injected cells by host structures represents an important challenge in cell based therapies for regenerative medicine purposes. Cell immobilization in hydrogels for target cell delivery has been developed to circumvent this issue. However, the existing immobilization methodologies sometimes have several steps under wet conditions and present some drawbacks, including poor encaps...
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