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Brucelose humana: análise retrospetiva de casos clínicos suspeitos de infeção e...

Carbúnculo: uma doença rara em Portugal?

Sarampo em Portugal: a caminho da eliminação

Diversity and phylogeny of the Helicobacter pylori outer membrane protein-encod...

The genetic diversity and evolution of the homC gene was evaluated in a panel of approximately 200 clinical and reference strains, isolated from patients from different geographical origins and presenting different gastric diseases. PCR, sequencing and bioinformatics analyses were used. All the strains tested harboured a complete homC gene at a conserved locus. Phylogenetic reconstruction of homC showed a geogr...

High worldwide conservation of a Helicobacter pylori outer membrane protein

The genetic diversity and evolution of homD, coding for Helicobacter pylori outer membrane protein (OMP) was investigated in a panel of approximately 200 clinical and reference strains, isolated from patients from different geographical origins and presenting different gastric diseases. PCR, sequencing and bioinformatics analyses were used. The homD gene was present in all strains, at a conserved locus, and sho...

Estudo de dois membros da familia das proteínas da membrana externa de Helicoba...

Dissertação de mestrado em Microbiologia Clínica apresentada à Faculdade de Medicina, Universidade de Lisboa, 2011 ; Neste trabalho pretendeu se estudar a diversidade genética e evolução dos genes homC e homD, que codificam para OMPs de H. pylori, num painel de 192 estirpes isoladas de doentes de origem geográfica diferente e com diversas gastropatologias. Foram utilizadas as técnicas de PCR, sequenciação e fe...

Detecting Biothreat Agents: the Portuguese National Reference Laboratory Response

At present, the threat of a biological terrorist event with a dangerous pathogen and its insidious impact are among the most, yet least understood, threats to civil society today. The use of manufactured weapon, such as bomb, will produce consequences limited in time hence the most of the damage occurs immediately. By contrast, the use of a biological weapon is an extended process whose scope and timing cannot ...

Estudo de dois membros da família das proteínas da membrana externa de Helicoba...

Tese de mestrado, Microbiologia Clínica, Faculdade de Medicina, Universidade de Lisboa, 2011 ; Neste trabalho pretendeu-se estudar a diversidade genética e evolução dos genes homC e homD, que codificam para OMPs de H. pylori, num painel de 189 estirpes isoladas de doentes de origem geográfica diferente e com diversas gastropatologias. Foram utilizadas as técnicas de PCR e sequenciação e ferramentas de bioinfor...

Allelic Diversity among Helicobacter pylori Outer Membrane Protein Genes homB a...

Recombination is one of the main mechanisms contributing to Helicobacter pylori genomic variability. homB and homA are paralogous genes coding for H. pylori outer membrane proteins (OMPs). Both genes display allelic variation yielded by polymorphisms of the genes’ middle regions, with six different alleles. This study used bioinformatic and statistical analyses to evaluate whether the allelic diversity of homB ...

Clinical relevance and diversity of two homologous genes encoding glycosyltrans...

Helicobacter pylori is known to be a major cause of peptic ulceration. The jhp0562 gene, encoding a glycosyltransferase involved in the synthesis of the lipopolysaccharide, was associated with peptic ulcer disease (PUD) in children. The beta-(1,3)-galactosyltransferase [beta-(1,3)GalT] gene (jhp0563), involved in Lewis (Le) antigen expression, is highly similar to jhp0562. The clinical significance and diversit...