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Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...
Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, GilBackground. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...
Jejunal Perforation due to Primary Non-Hodgkin Lymphoma – a clinical case
Reis, Miguel; Interno do Internato Complementar de Cirurgia Geral, SESARAM, EPE Hospital Dr. Nélio Mendonça – Funchal, PortugalMalignant tumors of the small bowel are rare and represent 1-2% of all malignant conditions of the gastrointestinal tract. Lymphoma is the third most common malignant tumor of the small intestine after adenocarcinoma and carcinoid tumor, of which 60-80% are B cell neoplasms. Perfuration is a rare form of presentation and represents a surgical emergency. The authors present the clinical case of a male patient, 6...
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