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Electrochemical oxidation of tamoxifen revisited

Tamoxifen is a selective estrogen receptor modulator that is used as an adjuvant and/or chemotherapeutic agent for the treatment of all stages of hormone-dependent breast cancer. Currently there is a deep interest in the study of tamoxifen biotransformation and identification of metabolites since they can significantly contribute to the overall pharmacological or adverse effects of the drug. Accordingly, the st...

Biópsia hepática com agulha tru-cut guiada por videolaparoscopia em caprinos

Descreve-se a técnica de biópsia hepática com agulha tru-cut guiada por videolaparoscopia em 12 caprinos machos, castrados, hígidos, sem raça definida, distribuídos em dois grupos (G): G1, com cinco animais de 12 meses e G2, com sete de seis meses de idade. O procedimento foi realizado sob anestesia geral intravenosa com o animal em decúbito lateral esquerdo. O pneumoperitônio e a laparoscopia foram procedidos ...

Novos marcadores do prognóstico do acidente vascular agudo: outro olhar sobre a...

Unilateral progressive osseous heteroplasia

A 50-year-old male patient presented with firm subcutaneous nodules and plaques with a gritty texture, unilaterally affecting the left side of the trunk and the left limbs. These lesions had had a progressive course since early childhood and caused functional impairment. There was no family history of similar disorders. No phospho-calcium metabolism abnormalities were observed. Biopsies of the affected areas de...

Identificação molecular de nematóides de galhas, Meloidogyne spp.

2008

Identificação molecular de Heterodera glycines, o nematóide de cistos da soja.

2008

Identificação molecular do nematóide Pratylenchus brachyurus.

2008

Diagnóstico molecular para o nematóide Rotylenchulus reniformis.

2008

Neutrophilic dermatosis of the dorsal hands associated with hypopharyngeal carc...

Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare and recently described disorder regarded as a subset of neutrophilic dermatosis, similar to superficial pyoderma gangrenosum and pustular vasculitis. Many currently consider it to be a localized variant of Sweet Syndrome. We describe the case of a 63-year-old male patient with NDDH associated with hypopharyngeal carcinoma. A biopsy demonstrated change...

In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyp...

Ampelozizyphus amazonicus Ducke is a tree commonly found in the Amazon region and an extract of its stem bark is popularly used as an antimalarial and anti-inflammatory agent and as an antidote to snake venom. Ursolic acid; five lupane type triterpenes: betulin, betulinic acid, lupenone, 3ß-hydroxylup-20(29)-ene-27,28-dioic acid, and 2a,3ß-dihydroxylup-20(29)-ene-27,28-dioic acid, and three phytosteroids: stigm...