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Proteomic approach to Pseudomonas aeruginosa adaptive resistance to benzalkoniu...

Machado, Idalina; Coquet, Laurent; Jouenne, Thierry; Pereira, M. O.

This study aimed to assess the membrane modifications in Pseudomonas aeruginosa after continuous exposure to increasing doses of benzalkonium chloride (BC). Two different concentrations were used, 0.9 and 12.0 mM. Proteomic investigations revealed that the range of the outermembrane proteome alterations following continuous exposure is very low, i.e. about 10% and BC concentration dependent. Adapted cells revea...


Proteomic characterization of Benzalkonium Chloride- and Ciprofloxacin-adapted ...

Machado, Idalina; Coquet, Laurent; Jouenne, Thierry; Pereira, M. O.

Bacteria are able to adapt to several environmental stresses such as the presence of antimicrobial molecules and, as consequence, bacterial resistance may increase with increasing exposure to antimicrobials. The most impressive mechanism of the bacterial mode of life is their grow as part of a sessile community referred to as biofilm [1]. Biofilm formation is an important aspect of many bacterial diseases, espe...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia