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CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-mic...
Manning, Amity L; Bakhoum, Samuel F.; Maffini, Stefano; Melo, Clara C; Maiato, Helder; Compton, Duane AAccurate chromosome segregation during mitosis requires precise coordination of various processes such as chromosome alignment, maturation of proper kinetochoremicrotubule (kMT) attachments, correction of erroneous attachments, and silencing of the spindle assembly checkpoint (SAC). How these fundamental aspects of mitosis are coordinately and temporally regulated is poorly understood. Here we show that the tem...
Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microt...
Maffin, Stefano; Maia, Ana R. R.; Manning, Amity L.; Maliga, Zoltan; Pereira, Ana L.; Junqueira, Magno; Shevchenko, Andrej; Hyman, AnthonyEfficient chromosome segregation during mitosis relies on the coordinated activity of molecular motors with proteins that regulate kinetochore attachments to dynamic spindle microtubules [1]. CLASPs are conserved kinetochore- and microtubule-associated proteins encoded by two paralogue genes, clasp1 and clasp2, and have been previously implicated in the regulation of kinetochore-microtubule dynamics [2-4]. Howe...
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