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BDNF-induced local protein synthesis and synaptic plasticity
Leal, Graciano; Comprido, Diogo; Duarte, Carlos B.Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase...
Regulation of heterogeneous nuclear RiboNucleoProtein K (hnRNP K) by BDNF : cha...
Comprido, Diogo de Oliveira FerreiraNeurons are highly polarized cells, and the local synthesis of proteins at the synapse requires mechanisms to deliver specific transcripts to dendrites. The transport of newly synthesized mRNAs from the nucleus to dendrites is conducted by RNA granules that allow the delivery and stabilize transcripts. These granules are disassembled in response to synaptic stimulation and this is thought to release the mRNAs f...
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