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Caracterização fitoquímica e neurofarmacológica de plantas usadas na medicina t...
Coleta, Miguel Fernando Alves RamosNeste trabalho identificámos um conjunto de quatro plantas, nomeadamente o Hypericum perforatum L., a Melissa officinalis L., a Passiflora edulis Sims e a Tilia x europaea L., que são espontâneas da flora nacional ou que se encontram actualmente cultivadas no nosso país, e para as quais o seu uso tradicional indica uma potencial actividade sedativa ou ansiolítica. Os extractos destas plantas foram sumariamente ...
Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological act...
Coleta, Miguel; Campos, Maria Graça; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daSince the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABAA receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Lute...
Neuropharmacological evaluation of the putative anxiolytic effects of Passiflor...
Coleta, Miguel; Batista, Maria Teresa; Campos, Maria Graça; Carvalho, Rui; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daPassiflora edulis Sims together with several other plants of the genus Passiflora have been reported to possess anxiolytic properties. It has been suggested recently that flavonoids may be partly responsible for the neuropharmacological activity of these plants but there are still few data reporting the relation between the constituents of these plants and their activity. This work evaluated the anxiolytic/seda...
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