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Glucocorticoid programing of the mesopontine cholinergic system
Borges, Sónia Maria de Sousa; Coimbra, Bárbara Guimarães Salazar; Cunha, Carina Isabel Soares da; Silva, Ana Paula Ventura; Pinto, LuísaStress perception, response, adaptation, and coping strategies are individually distinct, and the sequel of stress and/or glucocorticoids (GCs) is also distinct between subjects. In the last years, it has become clear that early life stress is a powerful modulator of neuroendocrine stress-responsive circuits, programing intrinsic susceptibility to stress, and potentiating the appearance of stress-related disord...
Dopaminergic modulation of affective and social deficits induced by prenatal gl...
Borges, Sónia Maria de Sousa; Coimbra, Bárbara Guimarães Salazar; Cunha, Carina Isabel Soares da; Pêgo, José M.; Sousa, Nuno; Rodrigues, Ana JoãoPrenatal stress or exposure to elevated levels of glucocorticoids (GCs) can impair specific neurobehavioral circuits leading to alterations in emotional processes later in life. In turn, emotional deficits may interfere with the quality and degree of social interaction. Here, by using a comprehensive behavioral approach in combination with the measurement of ultrasonic vocalizations, we show that in utero GC (i...
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disea...
Carvalho, Miguel; Campos, Filipa L.; Coimbra, Bárbara Guimarães Salazar; Pêgo, José M.; Lima, Rui; Rodrigues, Ana João; Sousa, Nuno; Salgado, António J.BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic netwo...
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