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Synaptosomal signal transduction in Alzheimer's disease
Coelho, Edgar Duarte de Jesus Valente MarquesAlzheimer’s Disease (AD) is characterized by the presence of amyloid plaques (APs) and neurofibrillary tangles (NFTs), which consist of Abeta aggregates and hyperphosphorylated tau, respectively. It is known that increasing Abeta concentrations precede NFT production. Moreover, several lines of evidence suggest that the increase in APP and tau phosphorylation is the result of Abeta neurotoxicity. Although, the ...
Data: 2011
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Origem: RIA - Repositório Institucional da Universidade de Aveiro
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