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Triple Therapy with High-Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycli...

INTRODUCTION: Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. AIM: To evaluate the efficacy and safety of a triple therapy with proton-pump inhibitor (PPI), amoxicillin, and doxycycline in patients with multidrug-resistant H. py...

Carcinoma pancreático de células gigantes de tipo osteoclástico

Initially described 40 years ago (Rosai), the undifferentiated osteoclastic-type giant cell carcinoma (IOGCC) is a variant of ductal adenocarcinoma and accounts for less than 1% of exocrine pancreatic tumors. Its extreme rarity, with consequent existence of few reports and clinical experience, leads to the arousal of doubts with regard to its histogenesis, types of approach and therapeutical attitudes. It is im...

Glycogenic acanthosis of the esophagus: an unusually endoscopic appearance

Metastização Cólica: Uma forma rara de apresentação do carcinoma gástrico

O carcinoma gástrico é uma neoplasia com distribuição mundial, estando as fases avançadas da doença associadas à metastização à distância para múltiplos órgãos. Contudo, as metástases para o cólon são raras e habitualmente surgem como recidiva da doença, geralmente nos primeiros 5 anos após o diagnóstico. Os autores apresentam o caso clínico de um doente do sexo masculino, 69 anos de idade, com um quadro clínic...

Posttransplant lymphoproliferative disorders in patients with IBD on immunosupp...

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary dif...

BACKGROUND & AIMS: Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs via promoter hypermethylation (epigenetic modification), and less frequently via CDH1 mutations and loss of heterozygosity (LOH). We quantified the different 2nd hits in CDH1 occurring in neopla...

Primary leiomyoma of the liver: accurate preoperative diagnosis on liver biopsy

External validation of a classification for methylene blue magnification chromo...

BACKGROUND: Conventional endoscopy has low sensitivity, specificity, and interobserver agreement for the diagnosis of gastric atrophy, intestinal metaplasia, and dysplasia. Magnification chromoendoscopy (ME) may optimize the evaluation of premalignant gastric lesions. OBJECTIVE AND DESIGN: As part of a multicenter trial, we aimed at validating a previously proposed classification for gastric methylene blue ME a...

A role for atorvastatin and insulin combination in protecting from liver injury...

Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto-Kakizaki rats were ...

External validation of a classification for methylene blue magnification chromo...

Background: Conventional endoscopy has low sensitivity, specificity, and interobserver agreement for the diagnosis of gastric atrophy, intestinal metaplasia, and dysplasia. Magnification chromoendoscopy (ME) may optimize the evaluation of premalignant gastric lesions. Objective and Design: As part of a multicenter trial, we aimed at validating a previously proposed classification for gastric methylene blue ME ...