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Development of pyridine-containing macrocyclic copper(II) complexes: potential ...

Fernandes, A. S.; Costa, J.; Gaspar, J.; Rueff, J.; Cabral, M. F.; Cipriano, M.; Castro, M.; Oliveira, N. G.

The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...


Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...

Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.

Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...


Choledocal cysts: spectrum of imaging findings

Santiago, I; Maciel, J; Loureiro, R; Ruivo, C; Portilha, M; Gonçalves, B; Dias, N; Cipriano, M; Alves, F


Epithelial and submucosal lesions of the stomach: spectrum of CT findings

Santiago, I; Maciel, J; Canelas, A; Seco, M; Graça, B; Gonçalves, B; Dias, N; Cipriano, M; Alves, F


Adult nesidioblastosis.

Branco, Vítor A; Santos, Rui M; Cipriano, M Augusta; Tralhão, Guilherme; Otero, M; Moura, José A; Sousa, F Castro; Porto, Armando

In adults, endogenous hyperinsulinemic hypoglycaemia is almost invariably due to insulinoma. The authors describe a 29 year old patient with repeated postprandial symptomatic hypoglycaemias and negative prolonged fast test. Distal pancreatectomy was performed, directed by positive arteriographic testing. Histological examination revealed pancreatic nesidioblastosis and no tumoral lesion. Distinct pathogenetic, ...

Data: 2003   |   Origem: Acta Médica Portuguesa

Peripheral blood lymphocyte phenotype can predict rejection episodes after orth...

Perdigoto, R.; Paiva, A.; Freitas, A.; Brêda Coimbra, H.; Mota, O.; Ferrão, J.; Tomé, L.; Furtado, E.; Cipriano, M. A.; Geraldes, B.; Oliveira, F. J.

http://www.sciencedirect.com/science/article/B6VJ0-3XFKHGV-3V/1/21ca47d4f3a98743181f2d76010e13c3


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia