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Optimized electro- and wet-spinning techniques for the production of polymeric ...
Puppi, D.; Piras, A. M.; Chiellini, F.; Chiellini, E.; Martins, Albino; Leonor, I. B.; Neves, N. M.; Reis, R. L.This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabricati...
Development of a bioactive glass fiber reinforced starch-polycaprolactone compo...
Jukola, H.; Nikkola, L.; Gomes, Manuela E.; Chiellini, F.; Tukiainen, M.; Kellomaki, M.; Chiellini, E.; Reis, R. L.; Ashammakhi, N.For bone regeneration and repair, combinations of different materials are often needed. Biodegradable polymers are often combined with osteoconductive materials, such as bioactive glass (BaG), which can also improve the mechanical properties of the composite. The aim of this work was to develop and characterize BaG fiber reinforced starch–poly-ecaprolactone (SPCL) composite. Sheets of SPCL (30/70 wt %) were pro...
Biodegradable nanomats produced by electrospinning : expanding multifunctionali...
Ashammakhi, N.; Ndreu, A.; Piras, A. M.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Gomes, Manuela E.; Neves, N. M.; Chiellini, E.With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the techniqu...
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