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Multiple factor analysis of metachronous upper urinary tract transitional cell ...
Wang,P.; Luo,J.D.; Wu,W.F.; Wang,S.; Cai,S.L.; Shen,B.H.; Shi,S.F.; Wei,K.X.; Zhang,Z.G.; Chen,Z.D.Transitional cell carcinoma (TCC) of the urothelium is often multifocal and subsequent tumors may occur anywhere in the urinary tract after the treatment of a primary carcinoma. Patients initially presenting a bladder cancer are at significant risk of developing metachronous tumors in the upper urinary tract (UUT). We evaluated the prognostic factors of primary invasive bladder cancer that may predict a metachr...
A concerted DNA methylation/histone methylation switch regulates rDNA gene dosa...
Silva, Manuela; Viegas, Wanda; Lawrence, Richard J.; Early, Keith; Pontes, Olga; Chen, Z.; Neves, Nuno; Pikaard, Craig.S.Eukaryotes regulate the effective dosage of their ribosomal RNA (rRNA) genes, expressing fewer than half of the genes at any one time. Likewise, genetic hybrids displaying nucleolar dominance transcribe rRNA genes inherited from one parent but silence the other paraental set.We show that rRNA gene dosage control and nucleolar dominance utilize a common mechanism
Natural variation in nucleolar dominance reveals relationship between nucleolus...
Silva, Manuela; Viegas, Wanda; Pontes, Olga; Lawrence, Richard; Neves, Nuno; Lee, Jae-Hyeok; Chen, Z.; Pikaard, CraigIn genetic hybrids, nucleolus formation on chromosomes inherited from only one parent is the epigenetic phenomenon, nucleolar dominance. By using Arabidopsis suecica, the allotetraploid hybrid of Arabidopsis thaliana and Arabidopsis arenosa, natural variation in nucleolar dominance was found to occur, providing a unique opportunity to examine homologous nucleolus organizer regions (NORs) in their active and ina...
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