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Neuregulin attenuates pulmonary endothelial dysfunction in an experimental mode...

[abstract] ; [resumo]

A neuregulina-1 atenua a disfunção endotelial na hipertensão arterial pulmonar

[abstract] ; [resumo]

Neuregulin attenuates right ventricular hypertrophy and dysfunction in an exper...

[abstract] ; [resumo]

Edema Agudo do Pulmão Pós-Extubação Traqueal. Caso Clínico

O edema agudo do pulmão pós-extubação traqueal é um acontecimento raro (≈ 0,1%)1. A etiologia é multifactorial, sendo a obstrução da via aérea superior o factor desencadeante principal. O esforço inspiratório contra a glote encerrada causa pressões intra torácicas muito negativas, que se transmitem ao interstício pulmonar, condicionando uma transudação de fluidos a partir dos vasos capilares pulmonares1-5. Rela...

Negative inotropic effect of selective AT2 receptor stimulation and its modulat...

Inotropic and lusitropic effects of ghrelin and their modulation by the endocar...

Contractile effects of ghrelin (10(-9) to 10(-6) M) were tested in rat papillary muscles of normal (n = 50) and hypertrophic (n = 16) right ventricles (RV). RV hypertrophy was induced by pulmonary hypertension using monocrotaline. In normal muscles, ghrelin was added either alone (n = 9) or after pre-treatment with indomethacin (cycloxygenase inhibitor, 10(-5) M; n = 10), L-nitro-L-arginin (NO synthase inhibito...

Contractile effects of Ghrelin and expression of its receptor GHS-R1a in normal...

INTRODUCTION: Ghrelin, isolated in 1999, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a). Recent studies suggest that it may influence the function of normal and failing hearts. Nonetheless, it has been difficult to differentiate its effects on the intrinsic properties of the myocardium from the secondary effects resulting from growth hormone release and vasomotor action. This stu...

Hepatocellular carcinoma. Rare forms of presentation.

The occurrence of metastases is documented in a varied number of hepato-cellular carcinomas (HCC). The indicative metastasis is very rarely the form of clinical presentation of the disease. Two cases of HCC which were clinically presented in a secondary location, in the bone and skeletal muscle respectively, are described. ; The occurrence of metastases is documented in a varied number of hepato-cellular carci...

Clear cell hepatocellular carcinoma.

A case of a 62 year old white patient with mild dyspeptic symptoms and nodular hepatomegaly is presented. The histologic examination of a liver biopsy revealed a hepatocellular carcinoma clear cell variant. There were no signs of chronic hepatic failure. The disease showed an indolent clinical behaviour, thus the beginning of chemotherapy was delayed until clinical deterioration was obvious. Clinical improvemen...