Encontrados 105 documentos, a visualizar página 1 de 11
Chemical composition, antimicrobial, antioxidant and antitumor activity of Thym...
Nikolić, Miloš; Glamočlija, Jasmina; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Fernandes, Ângela; Marković, Tatjana; Marković, DejanAromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oils, commonly known as thyme oil: antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. The oil is also beneficial in boosting the immune system and helps to fight colds, flu, infectious diseases and chills. It i...
Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synth...
Heleno, Sandrina A.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Esteves, Ana Paula; Martins, Anabela; Queiroz, Maria João R.P.Coprinopsis atramentaria is a wild edible mushroom whose methanolic extract revealed a marked antioxidant activity; p-hydroxybenzoic (HA), p-coumaric (CoA) and cinnamic (CA) acids were identified in the extract. In the present work, the cytotoxicity of C. atramentaria extract, previously identified organic acids and their synthesized derivatives (methylated compounds and protected glucuronides) was evaluated. A...
Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artic...
Pereira, Carla; Calhelha, Ricardo C.; Barros, Lillian; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.Artichoke, borututu and milk thistle are three medicinal plants well-known for their capacity to prevent oxidative stress and many liver diseases. In a previous work, we reported the bioactivity of infusions and pills based on these plants; herein, the aim was to provide scientific information about the antioxidant and anti-hepatocellular carcinoma activities of syrups based on these medicinal plants and evalua...
Bioactivity of different enriched phenolic extracts of wild fruits from Northea...
Guimarães, Rafaela; Barros, Lillian; Calhelha, Ricardo C.; Carvalho, Ana Maria; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.Arbutus unedo, Prunus spinosa, Rosa micrantha and Rosa canina are good sources of phenolic compounds, including anthocyanins. These compounds have potent antioxidant properties, which have been related to anticancer activity. Herein, the in vitro antioxidant and antitumor properties of enriched phenolic extracts (non-anthocyanin phenolic compounds enriched extract- PE and anthocyanins enriched extract- AE) of t...
A detailed comparative study between chemical and bioactive properties of Ganod...
Stojković, Dejan; Barros, Lillian; Calhelha, Ricardo C.; Glamočlija, Jasmina; Ćirić, Ana; Van Griensven, Leo J.I.D.; Soković, MarinaA detailed comparative study on chemical and bioactive properties of wild and cultivated Ganoderma lucidum from Serbia (GS) and China (GCN) was performed. This species was chosen because of their worldwide use as medicinal mushroom. Higher amounts of sugars were found in GS, while higher amounts of organic acids were recorded in GCN. Unsaturated fatty acids predominated over saturated fatty acids. GCN revealed ...
Two-dimensional PCA highlights the differentiated antitumor and antimicrobial a...
Dias, Maria Inês; Barreira, João C.M.; Calhelha, Ricardo C.; Queiroz, Maria João R.P.; Oliveira, M.B.P.P.; Soković, Marina; Ferreira, Isabel C.F.R.Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples of L. nobilis were...
Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley...
Reis, Filipa S.; Barreira, João C.M.; Calhelha, Ricardo C.; Van Griensven, Leo J.I.D.; Ćirić, Ana; Glamočlija, Jasmina; Soković, MarinaMushrooms are widely appreciated for their organoleptic qualities, being also recognized as good sources of bioactive compounds that provide antioxidant, antimicrobial and cytotoxic activities. Polysaccharides (including glucans) are often pointed out as the most bioactive compounds isolated from mushrooms, but other molecules such as triterpenoids, might also be highlighted for their bioactivity. In scientific...
Cytotoxicity of portuguese propolis: the proximity of the in vitro doses for tu...
Calhelha, Ricardo C.; Falcão, Soraia; Queiroz, Maria João R.P.; Vilas-Boas, Miguel; Ferreira, Isabel C.F.R.With a complex chemical composition rich in phenolic compounds, propolis (resinous substance collected by Apis mellifera from various tree buds) exhibits a broad spectrum of biological activities. Recently, in vitro and in vivo data suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Port...
Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial partsand ident...
Rashed, Khaled N.; Ćirić, Ana; Glamočlija, Jasmina; Calhelha, Ricardo C.; Ferrreira, Isabel C.F.R.; Soković, MarinaThis present investigation was undertaken to study antimicrobial and cytotoxic activities ofdichloromethane, ethyl acetate, and methanol 80% extracts from Alnus rugosa L. aerial parts, as wellinvestigate the bio-active compounds of each extract. Antimicrobial activity of the mentioned extractsagainst various bacteria and fungi using microdilution method, and cytotoxicity against five differenthuman tumor cell l...
Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: ...
Calhelha, Ricardo C.; Peixoto, Daniela; Vilas-Boas, Miguel; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.The antioxidant activity of the aminodi(hetero)arylamines, prepared by C-N coupling of the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with bromonitrobenzenes and further reduction of the obtained nitro compounds, was evaluated by chemical, biochemical and electrochemical assays. The aminodi(hetero) arylamine with the amino group ortho to the NH and a methoxy group in para, was the most efficient in radic...
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