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Human bone marrow mesenchymal stem cells : a systematic reappraisal via the gen...
Charbord, Pierre; Livne, Erella; Gross, Gerhard; Häupl, Thomas; Neves, N. M.; Marie, Pierre; Bianco, Paolo; Jorgensen, ChristianGenostem (acronym for “Adult mesenchymal stem cells engineering for connective tissue disorders. From the bench to the bed side”) has been an European consortium of 30 teams working together on human bone marrow Mesenchymal Stem Cell (MSC) biological properties and repair capacity. Part of Genostem activity has been dedicated to the study of basic issues on undifferentiated MSCs properties and on signalling pat...
Osteogenic differentiation of human bone marrow mesenchymal stem cells seeded o...
Pinto, A. R.; Correlo, V. M.; Sol, Paula C.; Bhattacharya, Mrinal; Charbord, Pierre; Delorme, B.; Reis, R. L.; Neves, N. M.The purpose of this study was to evaluate the growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) when seeded onto new biodegradable chitosan/polyester scaffolds. Scaffolds were obtained by melt blending chitosan with poly(butylene succinate) in a proportion of 50% (wt) each and further used to produce a fiber mesh scaffold. hBMSCs were seeded on those structures ...
Adhesion, proliferation, and osteogenic differentiation of a mouse mesenchymal ...
Pinto, A. R.; Salgado, A. J.; Correlo, V. M.; Sol, P.; Bhattacharya, Mrinal; Charbord, Pierre; Reis, R. L.; Neves, M. N.The aim of the present work was to study the biological behavior of a mouse mesenchymal stem cell line when seeded and cultured under osteogenic conditions onto novel processed melt-based chitosan scaffolds. Scaffolds were produced by compression molding, followed by salt leaching. Scanning electron microscopy (SEM) observations and lCT analysis showed the pore sizes ranging between 250 and 500 lm and the inter...
Assessment of the suitability of chitosan/polybutylene succinate scaffolds seed...
Oliveira, João T.; Correlo, V. M.; Sol, P. C.; Pinto, A. R.; Malafaya, P. B.; Salgado, A. J.; Bhattacharya, Mrinal; Charbord, Pierre; Neves, N. M.In this work, scaffolds derived from a new biomaterial originated from the combination of a natural material and a synthetic material were tested for assessing their suitability for cartilage tissue engineering applications. In order to obtain a better outcome result in terms of scaffolds’ overall properties, different blends of natural and synthetic materials were created. Chitosan and polybutylene succinate (...
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