Encontrados 13 documentos, a visualizar página 1 de 2
Human skin cell fractions fail to self-organize within a gellan gum/Hyaluronic ...
Cerqueira, M. T.; Silva, L. P. da; Santos, T. C.; Pirraco, Rogério; Correlo, V. M.; Marques, A. P.; Reis, R. L.Split-thickness autografts still are the current gold standard to treat skin, upon severe injuries. Nonetheless, autografts are dependent on donor site availability and often associated to poor quality neoskin. The generation of dermal–epidermal substitutes by tissue engineering is seen as a promising strategy to overcome this problematic. However, solutions that can be safely and conveniently transplanted in o...
An investigation of the potential application of chitosan/aloe-based membranes ...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Teixeira, P.; Sousa, Cláudia; Mano, J. F.A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation beh...
Human adipose stem cells cell sheet constructs impact epidermal morphogenesis i...
Cerqueira, M. T.; Pirraco, R. P.; Santos, T. C.; Rodrigues, D. B.; Frias, A. M.; Martins, A.; Reis, R. L.; Marques, A. P.Among the wide range of strategies to target skin repair/regeneration, tissue engineering (TE) with stem cells at the forefront, remains as the most promising route. Cell sheet (CS) engineering is herein proposed, taking advantage of particular cell-cell and cell-extracellular matrix (ECM) interactions and subsequent cellular milieu, to create 3D TE constructs to promote full-thickness skin wound regeneration. ...
Interfollicular epidermal stem cells : boosting and rescuing from adult skin
Cerqueira, M. T.; Frias, A. M.; Reis, R. L.; Marques, A. P.Publicado na série "Methods in Molecular Biology", vol. 989 (2013), ISSN 1064-3745 ; Epidermal stem cells isolation struggle remains, mainly due to the yet essential requirement of well-defined approaches and markers. The herein proposed methodology integrates an assemblage of strategies to accomplish the enrichment of the interfollicular epidermal stem cells multipotent fraction and their subsequent separatio...
Functional cell microcarriers : a new platform for cell separation and expansion
Custódio, Catarina A.; Cerqueira, M. T.; Marques, A. P.; Reis, R. L.; Mano, J. F.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The success of many stem cell applications in the biomedical field is highly dependent on the development of separation techniques for isolation and purification of cells with a very high yield and purity. Despite all the achievements made in the field over the past several years, new systems for effective cell sep...
Combination of aloe vera improves the biological performance of chitosan membra...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Mano, J. F.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, suppl. 1 (2013) ; In the last years, aloe vera (AV), a tropical plant belonging to theliliaceaefamily, has gained popularity for medical, cosmetic and nutritional purposes. Commercially, AV appears in food supplements, as additive to drinks, coating fruits, moisturizer, and healing agent in cosmetic products, among others uses. The...
Human embryonic stem cell-derivatives in a hydrogel-based skin model
Cerqueira, M. T.; Silva, L. P. da; Sousa, R. A.; Correlo, V. M.; Marques, A. P.; Reis, R. L.Cases of massive skin loss upon injury or disease still represent a serious healthcare challenge worldwide, and despite the many alternatives available, results are not yet satisfactory. Skin Tissue Engineering, especially now combined with Stem Cell Research, holds great expectation towards an efficient and high quality skin regeneration. Human embryonic stem cells (hESCs) are quite attractive for this purpose...
Improved regeneration of mice full-thickness excisional wounds by human adipose...
Cerqueira, M. T.; Santos, T. C.; Pirraco, R. P.; Frias, A. M.; Martins, A. R.; Reis, R. L.; Marques, A. P.A totalidade dos resumos foram publicados em "J. Tissue Eng. Regen. Med. 2012; 6 (Suppl. 2) : 8–39."
Evaluation of the potential of polyhydroxybutyrate-co-hydroxyvalerate bi-layere...
Zonari, A. A. C.; Cerqueira, M. T.; Novikoff, S.; Goes, A. M.; Marques, A. P.; Correlo, V. M.; Reis, R. L.Polyhydroxybutyrate-co-hydroxyvalerate (PHB-HV) is natural-based polyester produced by microorganisms under unbalanced growth con- ditions. This polymer is known for its biocompatibility and biodegrad- ability and has been explored for tissue engineering approaches. The aim of this work was to create a bi-layered construct, based on PHB- HV, for skin tissue replacement. The PHB-HV bi-layered scaffold was produc...
The use of ionic liquids in the processing of chitosan/silk hydrogels for biome...
Silva, S. S.; Santos, T. C.; Cerqueira, M. T.; Marques, A. P.; Reys, L. L.; Silva, Tiago H.; Caridade, S. G.; Mano, J. F.; Reis, R. L.Natural polymers are adequate renewable resources for the processability of well-defined architectures for several applications. Combinations of polysaccharides and proteins may mimic the naturally occurring environment of certain tissues. The main goal of this work renders the application of green chemistry principles, namely the use of ionic liquids (ILs) and biorenewable sources, such as chitosan (CHT) and s...
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