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Sources of hepatic triglyceride accumulation during high-fat feeding in the hea...
Delgado, T. C.; Pinheiro, D.; Caldeira, M.; Castro, M. M. C. A.; Geraldes, C. F. G. C.; López-Larrubia, P.; Cerdán, S.; Jones, J. G.Hepatic triglyceride (HTG) accumulation from peripheral dietary sources and from endogenous de novo lipogenesis (DNL) was quantified in adult Sprague-Dawley rats by combining in vivo localized 1H MRS measurement of total hepatic lipid with a novel ex vivo 2H NMR analysis of HTG 2H enrichment from 2H-enriched body water. The methodology for DNL determination needs further validation against standard methodologie...
Preliminary characterization of an experimental breast cancer cells brain metas...
Simões, R.; Martinez-Aranda, A.; Martín, B.; Cerdán, S.; Sierra, A.; Arús, C.Abstract Purpose Chemotherapy increases survival in breast cancer patients. Consequently, cerebral metastases have recently become a significant clinical problem, with an incidence of 30–40% among breast carcinoma patients. As this phenomenon cannot be studied longitudinally in humans, models which mimic brain metastasis are needed to investigate its pathogenesis. Such models may later be used in experimental ...
Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepat...
Prata, M. I. M.; Santos, A. C.; Torres, S.; André, J. P.; Martins, J. A.; Neves, M.; García-Martín, M. L.; Rodrigues, T. B.; López-Larrubia, P.The characterization of a new class of hydrophilic liver-targeted agents for gamma-scintigraphy and MRI, consisting, respectively, of [153Sm]3+ or Gd3+ complexes of DOTA monoamide or bisamide linked glycoconjugates (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), is reported. In vitro studies show high uptake of radiolabeled [153Sm]-DOTAGal2 by the human hepatocyte carcinoma cell line Hep G2 c...
Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepat...
Prata, M. I. M.; Santos, A. C.; Torres, Susana; André, João P.; Martins, J. A. R.; Neves, M.; García Martín, M. L.; Rodrigues, T. B.; López Larrubia, P.The characterization of a new class of hydrophilic liver-targeted agents for gamma-scintigraphy and MRI, consisting, respectively, of [153Sm]3+ or Gd3+ complexes of DOTA monoamide or bisamide linked glycoconjugates (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), is reported. In vitro studies show high uptake of radiolabeled 153SmDOTAGal2 by the human hepatocyte carcinoma cell line Hep G2 cont...
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