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The proportions of dormant bacteria within Staphylococcus epidermidis biofilms ...

Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria...

Modulation of poly-N-acetylglucosamine accumulation within mature Staphylococcu...

PNAG is a major component of Staphylococcus epidermidis biofilms involved in intercellular adhesion as well as in the interaction of the biofilm with components of the host immune response. Synthesis of PNAG has been found to be regulated by several environmental factors. In the present study, the effect of glucose metabolism-dependent culture medium acidification in PNAG accumulation was evaluated. Established...

Comparative assessment of antibiotic susceptibility of coagulase-negative staph...

Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy ; Objectives: To quantitatively compare the antibiotic susceptibility of biofilms formed by the coagulasenegative staphylococci (CoNS) Staphylococcus epidermidis and Staphylococcus haemolyticus with the susceptibility of planktonic cultures. Methods: SeveralCoNSstrains were grown planktonically or as biofilms t...

A study on the immune response elicited in mice challenged with Staphylococcus ...

In this study a biofilm-forming strain of Staphylococcus epidermidis was used in order to evaluate, in a murine model, the immune response to bacteria grown either as planktonic cells or biofilm. Groups of male BALB/c mice were infected intra-peritoneally (i.p.), with 2×10^8 S. epidermidis cells per mice, obtained either from a mature biofilm (grown for 48h) or from a planktonic cell culture. Mice were sacrific...

Synergistic effects of combinations of antibiotics on coagulase negative staphy...

Background. Previous studies examining synergistic effects of antibiotics against CoNS biofilms often relied on drug concentrations higher than the peak serum (PS) concentration, as determined by MIC assays, therefore having little clinical applicability. Other studies investigated synergistic effects of a wide range of antibiotics, however many are not routinely used in a clinical setting. Dicloxacillin is the...