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Portuguese study of familial dilated cardiomyopathy: the FATIMA study

Dilated cardiomyopathy (DCM) is a myocardial disease, characterized by ventricular dilatation and impaired systolic function, that in more than 30% of cases has a familial or genetic origin. Given its age-dependent penetrance, DCM frequently manifests in adults by signs or symptoms of heart failure, arrhythmias or sudden death. The predominant mode of inheritance is autosomal dominant, and in these cases mutati...

Vulnerabilidade das Ilhas-Barreira e dinâmica da Ria Formosa na óptica da gestão

Dissertação mest., Gestão e conservação da natureza, Universidade do Algarve, 2007 ; O sistema de ilhas-barreira da Ria Formosa oferece excelentes condições a diversas actividades, das quais se podem salientar as turístico-balneares. Desde os anos 60 que essas actividades vêm sendo exercidas com grande intensidade, com a construção de infra-estruturas e cargas superiores ao limite de capacidade em algumas ilha...

Cardiac insufficiency. New physiopathological approaches and therapeutic implic...

Clinical pharmacokinetics. Present and future.

Individualized monitoring of the therapy with gentamycin using pharmacokinetic ...

Gentamicin has an excellent cost/efficacy ratio for gram negative infections treatment. Its use is often limited in clinical practice by its narrow safety margins and a high incidence of toxicity. Gentamicin related nephrotoxicity is a major adverse effect, mostly in patients with other concomitant potential risk factors. As many other Authors we have found in our Internal Medicine Service during 1992 a gentami...

Acute pulmonary edema. The therapeutic approach.

The management of acute pulmonary edema remains an interesting challenge to the clinician. The early recognition of this frequent condition, based on clinical features, must lead to the institution of general measures of therapy that can save most patients; a delay or mistake in this early treatment is lethal. The subsequent treatment depends on the characterization of the etiology and the pathophysiological ch...

Etiologic diagnosis of pleural effusions in the adult. A solved problem?.

Pleural effusion in adults is a common syndrome due to various local and systemic diseases. A careful clinical approach is very important for etiological diagnosis; pleural fluid examination and pleural biopsy are needed in almost all cases. Other techniques, like ultrasonography, computed tomography and thoracoscopy, may also be required. In this review article, the Author presents some diagnostic strategies, ...

Cefoxitin: its role in the therapy of anaerobic infections.

Cefoxitin is a second generation cephalosporin commonly used to treat anaerobic and mixed infections. The authors reviewed the recently published data about the efficacy of cefoxitin; its utility in different clinical entities, patterns of resistance and resistance mechanisms, indications and reliability of in vitro susceptibility testing. These data indicate the need for determining susceptibility patterns of ...