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Natural volatile extracts and therpenic hydrocarbons as potential antimicotic a...

Dias, Maria Carlos; Teixeira, Sandra; Cavaleiro, Carlos; Machado, Marisa; Dias, Nicolina


Essential oils from Distichoselinum tenuifolium: Chemical composition, cytotoxi...

Tavares, Ana Cristina; Gonçalves, Maria José; Cruz, Maria Teresa; Cavaleiro, Carlos; Lopes, Maria Celeste; Canhoto, Jorge; Ribeiro Salgueiro, Ligia

Ethnopharmacological relevance: Several aromatic plants and their essential oils are known to possess antimicrobial and anti-inflammatory properties. Distichoselinum tenuifolium (Lag.) Garcia Martin & Silvestre, an Iberian endemism, is traditionally used in the treatment of contact dermatitis and skin infections. However, the cellular mechanisms through which this plant exerts their beneficial effects are not k...


Screening of Five Essential Oils for Identification of Potential Inhibitors of ...

Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, Carlos

Nuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...


Screening of Five Essential Oils for Identification of Potential Inhibitors of ...

Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, Carlos

Nuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...


Essential oil of Daucus carota subsp. halophilus: Composition, antifungal activ...

Tavares, Ana Cristina; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Lopes, Maria Celeste; Canhoto, Jorge; Ribeiro Salgueiro, Ligia

Ethnopharmacological relevance: Essential oils are known to possess antimicrobial activity against a wide spectrum of bacteria and fungi. Daucus carota L. is used since olden times in traditional medicine, due to recognized therapeutic properties, namely the antimicrobial activity of their essential oils. Aim of the study: In the present study the composition and the antifungal activity of the oils of Daucus ca...


The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and eth...

Gago, Bruno; Nyström, Thomas; Cavaleiro, Carlos; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João; Lundberg, Jon O.

By acting as a bioreactor, affording chemical and mechanical conditions for the reaction between dietary components, the stomach may be a source of new bioactive molecules. Using gas chromatography-mass spectrometry we here demonstrate that, under acidic gastric conditions, ethyl nitrite is formed in µM concentrations from the reaction of red wine or distilled alcoholic drinks with physiological amounts of nitr...


Susceptibility of Helicobacter pylori to essential oil of Dittrichia viscosa su...

Miguel, Graça; Faleiro, Leonor; Cavaleiro, Carlos; Salgueiro, Lígia; Casanova, Joseph

The essential oil of Dittrichia viscosa subsp. revoluta and its fractions were assessed for anti-Helicobacter activity. The essential oil was isolated by hydrodistillation, submitted to flash column chromatography and analysed by gas chromatography, gas-chromatography coupled to mass spectrometry and 13C-nuclear magnetic resonance. The anti-Helicobacter activity was determined by incorporation of the crude esse...


Analysis of Juniperus communis subsp. alpina needle, berry, wood and root oils ...

Gonny, Marcelle; Cavaleiro, Carlos; Salgueiro, Ligia; Casanova, Joseph

The essential oils from needles, berries, wood and roots of Juniperus communis L. subsp. alpina were obtained by hydrodistillation, fractionated on column chromatography and analysed by GC, GC-MS and 13C-NMR. Chemical compositions of wood and root oils are reported here for the first time. Eighty-two, 65, 76 and 54 components were identified, respectively, in needle, berry, wood and root oils. The chemical comp...


Chemical variability of Juniperus oxycedrus ssp. oxycedrus berry and leaf oils ...

Boti, Jean Brice; Bighelli, Ange; Cavaleiro, Carlos; Salgueiro, Ligia; Casanova, Joseph

The composition of 27 samples of berry oil and 54 samples of leaf oil of Juniperus oxycedrus ssp. oxycedrus from Corsica was investigated by GC, GC-MS and 13C-NMR. The main constituents were terpene hydrocarbons, especially alpha-pinene, myrcene and germacrene D in the oils from berries and alpha-pinene, beta-phellandrene and Delta3-carene in the oils from leaves. The results of the analyses were submitted to k...


Antifungal activity of the essential oil of Thymus capitellatus against Candida...

Salgueiro, Lígia Ribeiro; Pinto, Eugénia; Gonçalves, Maria José; Costa, Inês; Palmeira, Ana; Cavaleiro, Carlos; Pina-Vaz, Cidália

The antifungal activity of Thymus capitellatus oils on Candida, Aspergillus and dermatophyte strains were studied. The essential oils were obtained from the aerial parts of the plants by water distillation and analysed by GC and GC-MS. Three chemotypes were characterized: 1,8-cineole (47.5%), 1,8-cineole/borneol (28.8% and 19.5%, respectively) and 1,8-cineole/linalyl acetate/linalool (27.5%, 20.0% and 17.0%, re...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia