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Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to n...
Santos-Carvalho, Ana; Álvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, CláudiaNeuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the d...
A construção narrativa da família em crianças com familiares alcoólicos: contri...
Cavadas,Cláudia Manuela Soares; Fonte,Carla Alexandra MartinsNo presente artigo descreve-se um estudo cujo objetivo se centra na identificação e compreensão dos significados e sentidos, narrativamente construídos e organizados por crianças com e sem familiares alcoólicos, relativamente à sua família. Esta investigação enquadra-se na necessidade atual de aprofundar o estudo do consumo de álcool e do seu impacto a nível familiar, principalmente no desenvolvimento das crian...
NPY in rat retina is present in neurons, in endothelial cells and also in micro...
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; Gouveia, DenisaNPY is present in the retina of different species but its role is not elucidated yet. In this work, using different rat retina in vitro models (whole retina, retinal cells in culture, microglial cell cultures, rat Müller cell line and retina endothelial cell line), we demonstrated that NPY staining is present in the retina in different cell types: neurons, macroglial, microglial and endothelial cells. Retinal c...
NPY Y1 receptor is not involved in the hemodynamic response to an acute cold pr...
Cavadas, Cláudia; Waeber, Bernard; Pedrazzini, Thierry; Grand, Daniela; Aubert, Jean-François; Buclin, Thierry; Grouzmann, EricThe vasoconstrictor neuropeptide Y (NPY) has been shown to down-regulate tyrosine hydroxylase expression in cultured adrenal chromaffin cells, which probably accounts for the higher plasma resting norepinephrine (NE) and epinephrine (E) concentrations observed in Y1 knock-out mice (Y1-/-) than in wild-type mice (Y1+/+). The aim of this work was to study the hemodynamic response of Y1-/- mice to an acute stimula...
Intracellular signaling mechanisms mediating catecholamine release upon activat...
Rosmaninho-Salgado, Joana; Araújo, Inês M.; Álvaro, Ana Rita; Duarte, Emília P.; Cavadas, CláudiaThe adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release f...
Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role...
Cavadas, Cláudia; Céfai, Daniel; Rosmaninho-Salgado, Joana; Vieira-Coelho, Maria Augusta; Moura, Eduardo; Busso, Nathalie; Pedrazzini, ThierryThe contribution of neuropeptide Y (NPY), deriving from adrenal medulla, to the adrenosympathetic tone is unknown. We found that in response to NPY, primary cultures of mouse adrenal chromaffin cells secreted catecholamine, and that this effect was abolished in cultures from NPY Y(1) receptor knockout mice (Y(1)-/-). Compared with wild-type mice (Y(1)+/+), the adrenal content and constitutive release of catecho...
Up-regulation of neuropeptide Y levels and modulation of glutamate release thro...
Silva, Ana P.; Xapelli, Sara; Pinheiro, Paulo S.; Ferreira, Raquel; Lourenço, Joana; Cristóvão, Armando; Grouzmann, Eric; Cavadas, CláudiaKainate-induced epilepsy has been shown to be associated with increased levels of neuropeptide Y (NPY) in the rat hippocampus. However, there is no information on how increased levels of this peptide might modulate excitation in kainate-induced epilepsy. In this work, we investigated the modulation of glutamate release by NPY receptors in hippocampal synaptosomes isolated from epileptic rats. In the acute phase...
Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adr...
Cavadas, Cláudia; Grand, Daniela; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the recepto...
NPY regulates catecholamine secretion from human adrenal chromaffin cells
Cavadas, Cláudia; Silva, António P.; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Accordingly, the constitutive and regulated release of both NPY and catecholamines was measured simultaneously in cultured human chromaffin cells. In addition, by using both RT-PCR and a combination of specific agonists and...
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