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Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A. R.; Martins, J.; Costa, A. C.; Fernandes, E.; Carvalho, F.; Ambrósio, A. F.; Cavadas, C.Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Although some studies have demonstrated that considerable amounts of MDMA reach the vitreous humor o...
Pharmacological properties of Tilia europeæ aqueous: screening anxiolytic/sedat...
Cotrim, M. D.; Figueiredo, I. V.; Cavadas, C.; Cunha, A. Proença da; Caramona, M. M.; Macedo, T. R. A.The extracts or infusions obtained from inflorescences of Tilia europeae have been used in popular medicine as a sedative/anxiolytic drug. The purpose of the present work was to evaluate these possible properties of this extract, by using different behavioural models. The extract, orally administered to mice, prolonged sleeping time, changed the level of anxiety, affected curiosity and locomotor activity and sh...
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