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Molecular determinants of the response to malaria therapeutics

Tese dout., Bioquímica, Universidade do Algarve, 2007 ; The overall aim of this thesis was the analysis of the genetic variability in genes coding for proteins important in drug metabolism. The analysis of the metabolism of antimalarial drugs, particularly amodiaquine, and the possible contribution of biotransformation for the susceptibility to the disease was also studied. The results obtained in the genotypi...