Encontrados 6 documentos, a visualizar página 1 de 1
Detection of the Epstein-Barr virus in blood and bone marrow mononuclear cells ...
Marques, Herlander; Catarino, Raquel; Domingues, Nelson; Barros, Eliane; Portela, Catarina; Almeida, Maria Inês; Costa, Sandra; Reis, R. M.The Epstein-Barr virus (EBV) is associated with a large spectrum of lymphoproliferative diseases. Traditional methods of EBV detection include the immunohistochemical identification of viral proteins and DNA probes to the viral genome in tumoral tissue. The present study explored the detection of the EBV genome, using the BALF5 gene, in the bone marrow or blood mononuclear cells of patients with diffuse large B...
The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...
Silva, Inês Hilário; Silva, Cristina Nogueira; Figueiredo, Tiago; Lombo, Liliana; Faustino, Ilda; Catarino, Raquel; Nogueira, Augusto; Pereira, DeolindaUncorrected proof ; Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the ...
Epstein-Barr virus in healthy individuals from Portugal.
Sousa, Hugo; Silva, João; Azevedo, Luís; Pinto-Correia, Ana L; Catarino, Raquel; Pinto, Daniela; Lopes, Carlos; Medeiros, RuiThe Epstein-Barr virus (EBV) persists for long periods in latent state inside B-lymphocytes after primary infections, and reactivation usually occurs associated to immunosuppression conditions of the host. Recently, the detection of EBV DNA in circulation has been suggested as a predictor marker for the development of EBV related malignancies.The aim of our study was to characterize the frequency of circulating...
Circulating DNA levels and cyclin D1 and telomerase genetic variability in canc...
Catarino, Raquel Jorge FerreiraCiências Biomédicas ; Biomedical Sciences
Nasopharyngeal carcinoma study: introduction and multidisciplinary perspective.
Breda, Eduardo; Catarino, Raquel; Coelho, Ana; Sousa, Hugo; Medeiros, RuiNasopharynx is a particular anatomic structure, located between the respiratory and digestive systems, and it is the geographic centre of all otorinolaringologic pathologies. Numerous filogenic, ontogenic and embryogenic factors contribute to the anatomic and physiologic structure of nasopharynx. These factors may directly contribute to the development of several pathologies, as the embryogenic pathology, or ev...
Polimorfismo no gene da Ciclina D1 em neoplasias associadas a vírus
Catarino, Raquel Jorge FerreiraDissertação de mestrado em Genética Molecular. ; A carcinogénese é um processo que envolve várias etapas e reflecte as alterações genéticas que promovem a transformação progressiva de células humanas normais em células altamente malignas. Nos últimos anos tem vindo a tornar-se clara a importância do estudo de genes de baixa penetrância, como os genes envolvidos na reparação de DNA e manutenção da integridade g...
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