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Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydroge...
Rocha, Susana; Costa, Elísio; Coimbra, Susana; Nascimento, Henrique; Catarino, Cristina; Rocha-Pereira, Petronila; Quintanilha, Alexandre; Belo, LuísHuman erythrocyte peroxiredoxin 2 (Prx2) is a typical 2-cys cytosolic peroxiredoxin with thiol-dependent hydrogen peroxide scavenger activity. In a previous work, we reported Prx2 erythrocyte membrane linkage in some Hereditary Spherocytosis patients and that it seemed to be related to oxidative stress. The aim of the present work was to determine if Prx2 linkage to erythrocyte membrane could be induced by oxid...
Protein deficiency balance as a predictor of clinical outcome in hereditary sph...
Rocha, Susana; Rebelo, Irene; Costa, Elísio; Catarino, Cristina; Belo, Luís; Castro, Elisabeth; Cabeda, José; Barbot, José; Quintanilha, AlexandreVertical and horizontal interactions between membrane constituents account for integrity, strength and deformability of the erythrocyte. Disruption of vertical interactions caused by membrane protein deficiencies in hereditary spherocytosis (HS), favor membrane vesiculation with development of spherocytic cells. Our aim was to evaluate the hematological and clinical presentation of HS according to the type and ...
Erythropoietin levels in the different clinical forms of hereditary spherocytosis
Rocha, Susan; Costa, Elísio; Catarino, Cristina; Belo, Luís; Castro, Elisabeth; Barbot, José; Quintanilha, Alexandre; Santos-Silva, AliceErythropoietin (EPO), the main growth factor responsible for the regulation of red blood cell production, may be overproduced when blood loss or haemolysis occurs. Patients with mild hereditary spherocytosis (HS) are able to maintain normal haemoglobin concentration, whereas typical and severe HS patients develop an anaemic state. Splenectomy usually reverses anaemia. We aimed to clarify the role of EPO in the ...
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