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Stress acts cumulatively to precipitate Alzheimer’s disease-like tau pathology ...
Sotiropoulos, I.; Catania, C.; Pinto, Lucilia G.; Silva, Rui; Pollerberg, G. Elizabeth; Takashima, Akihiko; Sousa, Nuno; Almeida, O. F. X.Stressful life experiences are likely tiological factors in sporadic forms of Alzheimer’s disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels correlate with the rate of cognitive impairment and extent of neuronal atrophy. Severity of cognitive deficits in AD correlates strongly with levels of perphosphorylated forms of the cytoskeletal protein TAU, an essential mediator of the...
Corticosteroid status influences the volume of the rat cingulate cortex – a mag...
Cerqueira, João; Catania, C.; Sotiropoulos, I.; Schubert, M.; Kalisch, R.; Almeida, O. F. X.; Auer, D. P.; Sousa, N.Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The functional correlates of these changes include deficits in cognitive performance and regulation of the hypothalamic–pituitary–adre- nal axis. Since other limbic structures which are intricately connected with the hippocampal formation, also play an important role in behavioural and neuroend...
Corticosteroid status influences the volume of the rat cingulate cortex : a magn...
Cerqueira, João; Catania, C.; Sotiropoulos, I.; Schubert, M.; Kalisch, R.; Almeida, O. F. X.; Auer, D. P.; Sousa, NunoProva tipográfica (In Press) ; Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The functional correlates of these changes include deficits in cognitive performance and regulation of the hypothalamic–pituitary–adrenal axis. Since other limbic structures which are intricately connected with the hippocampal formation, also play an important rol...
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