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Dexamethasone prevents interleukin-1beta-induced nuclear factor-kappaB activati...
Castro-Caldas, M.; Mendes, A. F.; Carvalho, A. P.; Duarte, C. B.; Lopes, M. C.AIMS: Glucocorticoids (GCs) exert some of their anti-inflammatory actions by preventing the activation of the transcription factor nuclear factor (NF)-kappaB. The GC-dependent inhibition of NF-kappaB may occur at different levels, but the mechanisms involved are still incompletely understood. In this work, we investigated whether the synthetic GC, dexamethasone (Dex), modulates the activity of NF-kappaB in the ...
Dexamethasone-induced and estradiol-induced CREB activation and annexin 1 expre...
Castro-Caldas, M.; Mendes, A. F.; Duarte, C. B.; Lopes, M. C. F.AIMS: Annexin 1 (ANXA1), a member of the annexin family of calcium-binding and phospholipid-binding proteins, is a key mediator of the anti-inflammatory actions of steroid hormones. We have previously demonstrated that, in the human lymphoblastic CCRF-CEM cell line, both the synthetic glucocorticoid hormone, dexamethasone (Dex), and the estrogen hormone, 17beta-estradiol (E2beta), induce the synthesis of ANXA1,...
Dexamethasone induces the secretion of annexin I in immature lymphoblastic cell...
Castro-Caldas, M.; Duarte, C. B.; Carvalho, A. P.; Lopes, M. C. FernandesThe mechanisms by which glucocorticoids (GC) regulate annexin I (ANXA1) secretion in different cells are still a matter of debate. The aims of this study were to evaluate the ability of dexamethasone (Dex) to induce ANXA1 secretion and to investigate the roles of the intracellular free Ca2+ concentration ([Ca2+]i), and of the GC receptor, on that process. For this purpose, the human immature lymphoblastic CCRF-...
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