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Study of hepatocellular function in the murine model following hepatic artery s...

Tralhão, JG; Abrantes, AM; Gonçalves, AC; Hoti, E; Laranjo, M; Martins, R; Oliveiros, B; Cardoso, D; Sarmento-Ribeiro, AB; Botelho, MF

PURPOSE: To investigate the impact of selective hepatic artery clamping (SHAC) in hepatocellular function. METHODS: Three groups of Wistar male rats were subjected to SHAC ischemia period of 60min: Group A continuous SHAC were subjected to SHAC ischemia period of 60min, Group B intermittent SHAC of 30min with 5min of reperfusion and Group C intermittent SHAC of 15min with 5min of reperfusion. Animals without SH...


Perioperative tumor cell dissemination in patients with primary or metastatic c...

Tralhão, JG; Hoti, E; Serôdio, M; Laranjeiro, P; Paiva, A; Abrantes, AM; Pais, ML; Botelho, MF; Castro e Sousa, F

INTRODUCTION: Although there is general correlation between the TNM stage of colorectal cancer (CRC) and its prognosis, there is often significant variability of tumor behaviour and individual patient outcome, which is unaccounted for by pathologic factors alone. Our aim was to estimate perioperative tumor cell dissemination in patients with primary or CRC liver metastases as a possible factor influencing the o...


Intermittent Pringle Maneuver and Hepatic Function: Perioperative Monitoring by...

Tralhão, JG; Hoti, E; Oliveiros, B; Abrantes, AM; Botelho, MF; Castro e Sousa, F

BACKGROUND: Intermittent Pringle maneuver or selective portal clamping often are used to control inflow during parenchymal liver transection. This study was designed to determinate whether these maneuvers are associated with adverse hepatic function. METHODS: Resection was performed without portal clamping in 17 patients (group 1). Selective continuous portal clamping was performed in 11 patients (group 2) and ...


Estudo experimental do impacto da clampagem selectiva da veia porta na função h...

Tralhão, JG; Abrantes, AM; Gonçalves, C; Carvalho, C; Portela, I; Laranjo, M; Oliveiros, B; Cardoso, D; Ribeiro, AB; Botelho, MF; Castro e Sousa, F

The influence of selective clamping of the elements of hepatic pedicle in the hepatocellular function and viability were evaluated in our department. AIM: Study the effect of selective clamping of the portal vein (CPV) in hepatocellular function in an animal model with normal liver. METHOD: Three groups of Wistar rats (males, 2 months) were subjected a CPV for 60 min: group A (n=21) submitted to a continuous ...



Alterações precoces dos enzimas hepáticos após colecistectomia: estudo prospect...

Milheiro, A; Diogo, C; Lapa, P; Cunha, MJ; Manso, E; Martins, L; Mártires, E; Pedroso de Lima, J; Castro e Sousa, F


Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorect...

Isidro, G; Laranjeira, F; Pires, A; Leite, J; Regateiro, FJ; Castro e Sousa, F; Soares, J; Castro, C; Giria, J; Brito, MJ; Medeira, A; Teixeira, R

Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC gene, the MYH polyposis is an autosomal recessive disease. The identification of individuals affected by MYH poly...


Water enema computed tomography (WE-CT) in the local staging of low colorectal ...

Caseiro-Alves, F; Gonçalo, Manuela; Ilharco, J; Agostinho, A; Castro e Sousa, F; Vilaça-Ramos, H

BACKGROUND: To determine the accuracy of computed tomography performed with a water enema application (WE-CT) in the local staging of low colorectal neoplasms and to compare the results with those of transrectal ultrasonography (TRUS). METHODS: Forty patients with low colorectal tumors were evaluated prospectively by CT with the simultaneous administration of a lukewarm rectal enema (0.5-1.5 L). Thin slices (5 ...


Pulmonary function after laparoscopic cholecystectomy in the elderly

Milheiro, A; Castro e Sousa, F; Oliveira, L; Matos, MJ

The results of laparoscopic cholecystectomy in a group of 52 patients older than 69 years (group 1) were compared with the results of the same operation in a group of 338 younger patients (group 2). In group 1, 23 per cent of patients had acute cholecystitis and 13 per cent were operated on after an episode of acute pancreatitis. In group 2, 8 per cent of patients had acute cholecystitis and 4 per cent were ope...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia