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Strategies to enhance the removal of Fluoroquinolones

Amorim, Catarina L.; Maia, Alexandra S.; Moreira, Irina S.; van Loosdrecht, Mark C.M.; Tiritan, Maria E.; Castro, Paula M.L.

Fluoroquinolones (FQs) are broad-spectrum antibiotics that play an important role in the treatment of serious bacterial infections. Currently, several FQs are available but ciprofloxacin (CPF), ofloxacin (OFL) and norfloxacin (NOR) are amongst the most worldwide prescribed antibiotics. Antibiotics can reach wastewater treatment plants (WWTP) from different routes. Thus removal of these contaminants during the b...


Studies on enantioselective biodegradation of fluoxetine

Moreira, Irina S.; Ribeiro, Ana R.; Amorim, Catarina L.; Tiritan, Maria E.; Castro, Paula M. L.

Fluoxetine (FLX) is a chiral fluorinated pharmaceutical indicated mainly for treatment of depression and is one of the most dispensed drugs in the world. There is a clear evidence of environmental contamination with this drug. Granular sludge sequencing batch reactors (SBR) constitute a promising technology for the treatment of effluents containing micropollutants. In this study, a SBR was operated in order to...


Pharmaceuticals biodegradation by activated sludge and pure cultures

Bessa, Vânia S.; Moreira, Irina S.; Maia, Alexandra S.; Tiritan, Maria E.; Castro, Paula M. L.

The occurrence of pharmaceuticals in the environment have been a topic of increasing concern. Most of the pharmaceuticals are not completely mineralized in the human body and are released on the sewage systems as the pharmaceutical itself and as their “biologically active” metabolites through excretion, as well as by improper elimination and disposal. Once current wastewater treatment plants (WWTPs) are not des...


Screening of growth promotional traits of five metal resistant pgpr – possible ...

Moreira, Helena Maria Gomes; Pereira, Sofia Isabel Almeida; Marques, Ana P. G. C.; Rangel, António O.S.S.; Castro, Paula M. L.


Methyl cellulose films containing natural extracts: antibacterial properties

Campos, Débora; Piccirillo, Clara; Pullar, Robert C.; Castro, Paula M. L.; Pintado, Manuela E.


Ecotechnologies as urban solutions for sustainable water management

Calheiros, Cristina S. C.; Monteiro, Cristina M.; Rangel, A.O.S.S.; Castro, Paula M. L.


Valorization of canned sardine and mackerel residues through the extraction of ...

Ferraro, Vincenza; Piccirillo, Clara; Carvalho, Ana P.; Castro, Paula M. L.; Pintado, Manuela E.


Enantioselective Degradation of Enantiomers of Fluoxetine Followed by HPLC- FD

Ribeiro, Ana R.; Maia, Alexandra S.; Moreira, Irina S.; Afonso, Carlos; Castro, Paula M.L.; Tiritan, Maria E.

Environmental fate assessment of chiral pharmaceuticals is an important issue and little information is known about enantioselectivity in the environment. This kind of information is important for regulamentation of pharmaceutical industry and chiral switching processes. Fluoxetine (FLX), an anti-depressant worldwide used, is a chiral pharmaceutical prescribed in racemic form, and its main metabolite norfl...


Enantioselective Determination of Fluoxetine and Norfluoxetine in Wastewater

Ribeiro, Ana R.; Maia, Alexandra S.; Moreira, Irina S.; Afonso, Carlos; Castro, Paula M.L.; Tiritan, Maria E.

Microbial degradation of chiral compounds during wastewater treatment processes can be enantioselective and needs chiral analytical methodology to discriminate the biodegradation of both enantiomers. An enantioselective HPLC-FD method was developed and validated to monitor the degradation of fluoxetine (FLX) enantiomers by wastewater and the possible formation of its metabolite norfluoxetine (NFLX). The So...


Degradation of Fluoroquinolone Antibiotics and Identification of Metabolites/Tr...

Maia, Alexandra S.; Ribeiro, Ana R.; Amorim, Catarina L.; Barreiro, Juliana C.; Cass, Quezia B.; Castro, Paula M.L.; Tiritan, Maria E.

Antibiotics are a therapeutic class widely found inenvironmental matrices and extensively studied due to its persistence and implications for multi-resistant bacteria development. Degradation of four fluoroquinolone antibiotics, namely Ofloxacin (OFL), Norfloxacin (NOR), Ciprofloxacin (CPF) and Moxifloxacin (MOX), at 10 mg L-1 using a mixed bacterial culture, was assessed for 60 days. The assays were follow...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia