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Sexual reproduction of the pentaploid, short-styled Oxalis pes-caprae allows th...

Reproduction is a key factor for the successful establishment and spread of introduced species. Oxalis pes-caprae is a tristylous species with a self- and morph-incompatibility sexual system that, in the invaded range of the western Mediterranean Basin, has been found to reproduce asexually because only the pentaploid, short-styled morph (5x S-morph) was introduced. The objective of this study was to test the a...

Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies...

The bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has shown anti-diabetic effects by in vitro studies in Wistar (W) rat adipocytes and in vivo in obese Zucker rats. The aim of this work is to confirm the therapeutic properties of VO(dmpp)2 in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. An in vivo study was carried out, treating W and GK rats during 21 days with a daily dose of V...

Teste no tempo: da teoria clássica da administração à organização atual d...

Abcesso Pulmonar e Infecçáo por Citomegalovírus em Lactente. Caso Clínico

O abcesso pulmonar é raro na idade pediátrica. Com um quadro sintomático arrastado, causa uma morbilidade significativa nas crianças.Inovadoras técnicas de diagnóstico, os antibióticos e possibilidade de cirurgia, diminuiram a gravidade desta patologia.A infecção por Citomegalovírus é a mais frequente infecção congénita na criança. Quase sempre inaparente, é fundamental o conhecimento da sua epidemiologia, viro...

Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies...

The bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has shown anti-diabetic effects by in vitro studies in Wistar (W) rat adipocytes and in vivo in obese Zucker rats. The aim of this work is to confirm the therapeutic properties of VO(dmpp)2 in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. An in vivo study was carried out, treating W and GK rats during 21 days with a daily dose of V...

Small ruminants as a fire management tool in a Mediterranean mountain region

Presentation ; Small ruminants as a fire management tool in a Mediterranean mountain region Castro M. and Fernández-Núñez E. Forests represent a key-resource for the Mediterranean region and have supplied wood and non-wood products for centuries. Socioeconomic transformations of last decades in rural areas convert these areas into bombs-clock able of blowing up every summer. Actually, Southern Europe ...

[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...

The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human ser...

The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3- dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2,3-dimethyl-5- hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3), are synthesized and their structures determined by single crystal X-ray diffraction. The acid–base properties of 1 are studied by potentiometric and spectrophotom...

Unveiling the Interaction of Vanadium Compounds with Human Serum Albumin by Usi...

The binding of the VV oxidation products of two vanadium( IV) compounds, [VO(dmpp)2] and [VO(maltolato)2], which have shown promising anti-diabetic properties, to human serum albumin (HSA) in aqueous aerobic solution has been studied by 1H saturation transfer difference (STD) NMR spectroscopy and computational docking studies. Group epitope mapping and docking simulations indicate a preference of HSA binding to...

The human umbilical cord tissue-derived MSC population UCX® promotes early moto...

Mesenchymal stromal cells (MSCs) play an important role in tissue regeneration mainly through the secretion of trophic factors that enhance the repair of damaged tissues. The main goal of this work was to study the paracrine mechanisms by which an umbilical cord tissue-derived MSC population (UCX®) promotes the migration capacity of human dermal fibroblasts and keratinocytes, which is highly relevant for skin r...