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Miocene dinoflagellate cyst assemblages : preliminary correlation between the L...

Frequency of TERT promoter mutations in human cancers

Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...

Miocene dinoflagellate cyst assemblages: preliminary correlation between the Lo...

Biostratigraphic studies of several sections and a borehole (Belverde) of the Lower Tagus Basin, based on Miocene dinoflagellate cyst assemblages, have allowed a detailed stratigraphic investigation to be conducted. Assemblages are very diverse and abundant and can be used as important biostratigraphic guides. Recently, a palynostratigraphic study based on dinoflagellate cysts was conducted in two offshore well...

Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...