Encontrados 5 documentos, a visualizar página 1 de 1
The prognostic role of intragenic copy number breakpoints and identification of...
Carvalho, Diana; Mackay, Alan; Bjerke, Lynn; Grundy, Richard G.; Lopes, Celeste; Reis, R. M.; Jones, ChrisBACKGROUND: Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As functionally important intragenic copy number aberrations (iCNA) and fusion genes begin to be identified in adult HGG, the same has not yet been done in the childhood setting. We applied an iCNA algori...
Impaired glucose transporter-1 degradation and increased glucose transport and ...
Rosa, Susana C.; Gonçalves, Juliana; Judas, Fernando; Mobasheri, Ali; Lopes, Celeste; Mendes, Alexandrina F.Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intr...
Screening of Five Essential Oils for Identification of Potential Inhibitors of ...
Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, CarlosNuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
Assessment of strategies to increase chondrocyte viability in cryopreserved hum...
Rosa, Susana Carvalho; Gonçalves, Juliana; Judas, Fernando; Lopes, Celeste; Mendes, Alexandrina FerreiraObjective: Allogeneic cartilage is used to repair damaged areas of articular cartilage, requiring the presence of living chondrocytes. So far, no preservation method can effectively meet that purpose. Identification of more effective cryoprotective agents (CPAs) can contribute to this goal. The aim of this study was to determine whether the glycosylated hydroquinone, arbutin, alone or in combination with low co...
Screening of Five Essential Oils for Identification of Potential Inhibitors of ...
Neves, Ângela; Rosa, Susana; Gonçalves, Juliana; Rufino, Ana; Judas, Fernando; Salgueiro, Lígia; Lopes, Celeste; Cavaleiro, CarlosNuclear factor-κB is a key transcription factor activated by pro-inflammatory signals, like interleukin-1β (IL-1), being required for the expression of many inflammatory and catabolic mediators, such as nitric oxide (NO), that play an important role in arthritic diseases. This work aimed at screening and identifying natural inhibitors of IL-induced NF-κB activation and NO production in human articular chondrocy...
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