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Selective stimulation of catecholamine release from bovine adrenal chromaffin c...
Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.Background 2-Methylthioadenosine 5'-triphosphate (2-MeSATP), formerly regarded as a specific P2Y (metabotropic) purinergic receptor agonist, stimulates Ca2+ influx and evokes catecholamine release from adrenal chromaffin cells. These cells express P2Y and P2X (ionotropic) purinoceptors, with the latter providing an important Ca2+ influx pathway. Using single cell calcium imaging techniques, we have determined ...
Functional distribution of Ca2+-coupled P2 purinergic receptors among adrenergi...
Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.Background Adrenal chromaffin cells mediate acute responses to stress through the release of epinephrine. Chromaffin cell function is regulated by several receptors, present both in adrenergic (AD) and noradrenergic (NA) cells. Extracellular ATP exerts excitatory and inhibitory actions on chromaffin cells via ionotropic (P2X) and metabotropic (P2Y) receptors. We have taken advantage of the actions of the purin...
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