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Linfoma de Burkitt manifestando-se como dupla invaginação intestinal em criança...
Horta Oliveira, Patrícia; Piedade, Cláudia; Brito, Manuel; Ramos, Manuel; Ochoa de Castro, AntónioO diagnóstico diferencial de abdómen agudo em crianças infectadas por VIH (Vírus da Imunodeficiência Humana) inclui um amplo espectro de etiologias.Apresentamos o caso de uma criança infectada por VIH que se apresentou com uma oclusão intestinal secundária a dupla invaginação, tendo como ponto de partida um linfoma de Burkitt. A invaginação intestinal não deve ser esquecida no diagnóstico diferencial da oclusão...
Análise da qualidade dos serviços das piscinas públicas cobertas da Madeira na ...
Castro, António Miguel Trindade Pita Nunes deO propósito do estudo foi estudar a qualidade do serviço das piscinas públicas cobertas da RAM através do índice de satisfação dos utilizadores do setor lazer e recreação, bem como identificar o perfil destes praticantes. O estudo envolveu a participação de 410 utilizadores regulares, integrados em atividades de clubes ou outras entidades e de nado livre, maiores de 16 anos, os quais foram inquiridos através da...
Evidence for diversifying selection in a set of Mycobacterium tuberculosis gene...
Osório, Nuno S.; Rodrigues, Fernando; Gagneux, Sebastien; Pedrosa, Jorge; Pinto-Carbó, Marta; Castro, António G.; Young, Douglas; Comas, IñakiThe authors acknowledge Margarida Correia-Neves and Catarina L. Santos for helpful comments and suggestions ; Tuberculosis (TB) is a global health problem estimated to kill 1.4 million people per year. Recent advances in the genomics of the causative agents of TB, bacteria known as the Mycobacterium tuberculosis complex (MTBC), have allowed a better comprehension of its population structure and provided the fo...
In vivo performance of chitosan/soy-based membranes as wound dressing devices f...
Santos, T. C.; Hoering, B.; Reise, Kathrin; Silva, S. S.; Oliveira, Joaquim M.; Mano, J. F.; Castro, António G.; Reis, R. L.; Griensven, Martijn vanWound management represents a major clinical challenge on what concerns healing enhancement and pain control. The selection of an appropriate dressing plays an important role in both recovery and esthetic ap- pearance of the regenerated tissue. Despite the wide range of available dressings, the progress in the wound care market relies on the increasing interest in using natural-based biomedical products. Herein...
VEGF and FGF-2 incorporation in starch-based bone tissue engineering constructs...
Santos, T. C.; Morton, Tatjana J.; Moritz, Martina; Pfeifer, Sabine; Reise, Kathrin; Marques, A. P.; Castro, António G.; Reis, R. L.The ideal bone tissue-engineered (TE) construct remains to be found, although daily discoveries significantly contribute to improvements in the field and certainly have valuable long-term outcomes. In this work, different TE elements, aiming at bone TE applications, were assembled and its effect on the expression of several vas- cularization/angiogenesis mediators analyzed. Starch/polycaprolactone (SPCL) scaffo...
Poor immune reconstitution in HIV-infected patients associates with high percen...
Horta, Ana; Nóbrega, Cláudia; Machado, Pedro Amorim; Teixeira, Vítor Emanuel Coutinho; Silva, Palmira Barreira; Boavida, Susana; Costa, Patrício SoaresCD4(+) regulatory T cells (Tregs) are essential for the maintenance of the immune system's equilibrium, by dampening the activation of potential auto-reactive T cells and avoiding excessive immune activation. To correctly perform their function, Tregs must be maintained at the right proportion with respect to effector T cells. Since this equilibrium is frequently disrupted in individuals infected with the human...
Modelação molecular de péptidos com potencial imunogénico em membranas lipídicas
Castro, António José FelgueirasDissertação de mestrado em Biofísica e Bionanossistemas ; O uso de lipossomas como portadores de biomoléculas, apresenta-se como um marco importante na produção de vacinas ou de sistemas drug-delivery, usados para libertação controlada de fármacos, de marcadores para diagnóstico, entre outras aplicações. Na sua aplicação em vacinas, o uso de lipossomas apresenta a vantagem de conseguir manter antigénios (p.e. ...
Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...
Carmona, J. A.; Cruz, Andrea; Teixeira, Lucia de Fatima Moreira; Sousa, Carole Lara Veiga de; Sousa, Jeremy; Osório, Nuno S.; Saraiva, Ana L.Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...
Phage therapy is effective against infection by Mycobacterium ulcerans in a mur...
Trigo, Gabriela; Martins, Teresa G.; Fraga, Alexandra G.; Longatto Filho, Adhemar; Castro, António G.; Azeredo, Joana; Pedrosa, JorgeAuthor Summary : Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is a necrotizing disease of the skin, subcutaneous tissue and bone. Standard treatment of BU patients consists of a combination of the antibiotics rifampicin and streptomycin for 8 weeks. However, in advanced stages of the disease, surgical resection of the destroyed skin is still required. The use of bacterial viruses (bacteriophages) for th...
The novel Fh8 and H fusion partners for soluble protein expression in Escherich...
Costa, Sofia Judite; Almeida, André; Castro, António G.; Domingues, Lucília; Besir, HüseyinThe Escherichia coli host system is an advantageous choice for simple and inexpensive recombinant protein production but it still presents bottlenecks at expressing soluble proteins from other organisms. Several efforts have been taken to overcome E. coli limitations, including the use of fusion partners that improve protein expression and solubility. New fusion technologies are emerging to complement the tradi...
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