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Numerical and experimental investigations of three-dimensional container fillin...
Tomé, M. F.; Castelo, A.; Nóbrega, J. M.; Carneiro, O. S.; Paulo, G. S.; Pereira, F. T.This work employs numerical and experimental approaches to investigate three-dimensional container filling with Newtonian viscous fluids. For this purpose, a computer code developed for simulating three-dimensional free surface flows has been used. The CFD Freeflow3D code was specifically designed to deal with unsteady three-dimensional flows possessing multiple moving free surfaces. An experimental apparatus t...
Texture image analysis in differentiating malignant from benign adrenal cortica...
Shirata, Neuza Kasumi; Sredni, S. T.; Castelo, A.; Santanelli, A.; Mendon??a, B.; Montironi, R.; Longatto Filho, Adhemar; Zerbini, M. C. N.OBJECTIVE: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT). PATIENTS AND METHODS: Forty-eight cases of clinically benign (n=40) and clinically malignant (n=8) ACT with a minimum of 5-years' follow-up were evaluated for chromatin texture parameters (run length, stand...
The association of p16INK4A and fragile histidine triad gene expression and cer...
Longatto Filho, Adhemar; Etlinger, Daniela; Pereira, Sónia Maria Miranda; Kanamura, Cristina Takami; Loreto, Celso di; Santos, Gilda da CunhaObjective. This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16INK4A and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. Materials and Methods. Women seen at Pe´ rola Byington Hospital, São Paulo, Brazil, with histologically confirmed cervicitis (n = 31), cervical intraepithelial neoplasia (CIN) 1 (n = 30), CIN 2,3 (n = 3...
Risk factors for poor immune response to influenza vaccination in elderly people
Bellei,N.C.J.; Carraro,E.; Castelo,A.; Granato,C.F.H.Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. Some studies have pointed out low immunogenicity in this group. Health status has been poorly investigated as a risk factor that may influence the immune response to influenza vaccine. We established an immunization response study of a highly-matched elderly population in a nursing ho...
HIV-1 viremia during the first 28 weeks of pregnancy is not associated with mot...
Senise,J.F.; Palacios,R.; Tanno,Z.N.; Lunardi,L.; Waghabi,G.R.; Vaz,M.J.R.; Diaz,RS.; Castelo,A.It is currently recommended that antiretroviral prophylaxis to prevent mother-to-child transmission (MTCT) of HIV be initiated at 14 weeks of gestation. However, the relevance of early-gestation HIV viral load level for intrauterine MTCT is unknown. The objective of this study was to determine the relationship between prenatal maternal viral load and intrauterine MTCT. Records of HIV-infected pregnant women in ...
Performance of the DNA-citoliq liquid-based cytology system compared with conve...
Alves, Venâncio Avancini Ferreira; Castelo, A.; Filho, A. L.; Vianna, M. R.; Taromaru, Eliane; Namiyama, Gislene; Lörincz, A.; Dôres, Gerson B. dasTo evaluate the performance of a new, manual, simplified liquid-based system, DNA-Citoliq (Digene Brasil), employed under routine conditions as compared to conventional smears collected from six collaborating private laboratories. Methods: A panel of cytopathologists, who served as the gold standard diagnosis, adjudicated discordant opinions. Results: Of 3206 pairs of slides considered valid for comparison, the...
Screening for cervical Cancer in high-risk populations : DNA pap test or hybrid...
Pereira, Sónia Maria Miranda; Castelo, A.; Makabe, Sérgio; Utagawa, Maria Lúcia; Loreto, Celso di; Maeda, Marina Yoshiê Sakamoto; Marques, José A.This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervi...
Desenvolvimento de uma estratégia para otimizar a indicação de endoscopia diges...
Coelho-Filho,J.M.; Lima,J.W. de O.; Furtado,G.B.; Castelo,A.OBJETIVO: Desenvolver uma estratégia capaz de otimizar a indicação de endoscopia digestiva alta (esofagogastroduodenoscopia-EGD) em pacientes com dispepsia e sem sinal de alarme para doença orgânica, baseada em variáveis clínicas e sociais com maior valor em discriminar indivíduos com EGD com alteração de indivíduos com EGD normal. CASUÍSTICA E MÉTODO: 200 pacientes (idade: 16-76 anos) com dispepsia e sem evidê...
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